National Institute of Cancer Research, National Health Research Institutes, Zhunan, Miaoli County, Taiwan.
Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Biomed Pharmacother. 2018 Jun;102:242-248. doi: 10.1016/j.biopha.2018.03.077. Epub 2018 Mar 22.
Long non coding RNAs (lncRNAs) are involved in modulating the expression of other non-coding RNAs (ncRNA), such as microRNAs, or target proteins through the epigenetic, transcriptional, or post-transcriptional regulations. Genomic mutations in cancer reside inside regions that do not code for proteins and these regions are often transcribed into long non coding RNAs (lncRNAs). Emerging evidences have revealed an intense involvement of lncRNAs in the cancer development and progression. Recently, emerging evidences have depicted that the phytochemicals interact with lncRNAs to modulate their activities. Such findings are highly important for the identification of therapeutic strategies against diseases that are particularly associated with an aberrant lncRNA signaling. This review aims at deciphering the role of lncRNAs in the cancer development and progression, and their regulation by various phytochemicals.
长非编码 RNA（lncRNAs）通过表观遗传、转录或转录后调控，参与调节其他非编码 RNA（ncRNA），如 microRNA 或靶蛋白的表达。癌症中的基因组突变位于不编码蛋白质的区域内，这些区域通常被转录为长非编码 RNA（lncRNAs）。越来越多的证据表明，lncRNAs 强烈参与癌症的发生和发展。最近，越来越多的证据表明，植物化学物质与 lncRNAs 相互作用以调节它们的活性。这些发现对于确定针对与异常 lncRNA 信号特别相关的疾病的治疗策略非常重要。本综述旨在阐明 lncRNAs 在癌症发生和发展中的作用，以及它们被各种植物化学物质的调节。
