Wu Pin-Geng, Zhang Yu-Xi
Department of Urology, The First Hospital Affiliated to China Medical University, Shenyang, Liaoning 110001, China.
Zhonghua Nan Ke Xue. 2018 Aug;24(8):735-739.
In the human genome, there is a group of RNAs, called long non-coding RNA (lncRNA) with do not have the function of encoding proteins and whose transcript length is greater than 200 nucleotides. The disorders of lncRNAs are often involved in the occurrence and progression of malignant tumors. A large number of studies have indicated the aberrant expression of lncRNAs in prostate cancer (PCa) can regulate gene expressions at epigenetic, transcriptional and post-transcriptional levels and cause changes in the biological behaviors of PCa cells. Some lncRNAs have been shown to be closely related to the castration resistance of PCa. In recent years, a variety of lncRNAs have been detected in the PCa tissue, prostatic fluid, serum, and urine, and somehow influenced radiotherapy and chemotherapy of tumors. The expressions of some lncRNAs are also associated with disease prognosis. Thus, lncRNAs are expected to become new diagnostic markers and a therapeutic target for PCa. This review focuses on the roles and action modes and mechanisms of some lncRNAs as well as their potential value of clinical application in the diagnosis, treatment and prognosis of PCa.
在人类基因组中，存在一类RNA，称为长链非编码RNA（lncRNA），它们不具备编码蛋白质的功能，其转录本长度大于200个核苷酸。lncRNAs的紊乱常常与恶性肿瘤的发生和发展有关。大量研究表明，lncRNAs在前列腺癌（PCa）中的异常表达可在表观遗传、转录和转录后水平调节基因表达，并导致PCa细胞生物学行为的改变。一些lncRNAs已被证明与PCa的去势抵抗密切相关。近年来，在PCa组织、前列腺液、血清和尿液中检测到多种lncRNAs，并在一定程度上影响了肿瘤的放疗和化疗。一些lncRNAs的表达还与疾病预后相关。因此，lncRNAs有望成为PCa新的诊断标志物和治疗靶点。本综述重点关注一些lncRNAs在PCa诊断、治疗和预后中的作用、作用方式和机制及其潜在的临床应用价值。
