Bian Shiqi, Zhu Zhijun, Sun Liying, Wei Lin, Qu Wei, Zeng Zhigui, Liu Ying
Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China (mainland).
Liver Transplantation Center, National Clinical Research Center for Digestive Diseases (NCRC-DD), Beijing Friendship Hospital, Capital Medical University, Beijing, China (mainland).
Ann Transplant. 2018 Mar 23;23:197-206. doi: 10.12659/AOT.908774.
BACKGROUND Normothermic machine perfusion (NMP) is a novel strategy used for organ preservation. We aimed to determine the overall efficacy of NMP for liver preservation versus traditional static cold storage (CS). MATERIAL AND METHODS We performed a meta-analysis of the literature to evaluate the efficacy of NMP in experimental pig models of liver preservation. We use the standardized mean difference and 95% confidence intervals (CI) to calculate statistics and used the random effects model for the combined analysis of the results. RESULTS A total of 16 studies from 12 published articles were included. The combined results showed that NMP significantly decreased alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hyaluronic acid levels in serum or perfusate, significantly increased bile production, and had a similar 5-7-days survival rate after liver transplantation compared with the CS group. CONCLUSIONS NMP provides superior graft preservation compared with CS in the pig model.
背景 常温机器灌注（NMP）是一种用于器官保存的新策略。我们旨在确定NMP相较于传统静态冷藏（CS）用于肝脏保存的总体效果。材料与方法 我们对文献进行了荟萃分析，以评估NMP在肝脏保存实验猪模型中的效果。我们使用标准化均数差和95%置信区间（CI）来计算统计数据，并使用随机效应模型对结果进行综合分析。结果 共纳入了12篇已发表文章中的16项研究。综合结果显示，与CS组相比，NMP显著降低了血清或灌注液中的丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和透明质酸水平，显著增加了胆汁生成，并且肝移植后5 - 7天的生存率相似。结论 在猪模型中，NMP相较于CS能提供更好的移植物保存效果。
