Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Department of Maxillofacial Biomedical Engineering, School of Dentistry, and Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul, South Korea.
Exp Mol Med. 2018 Mar 23;50(3):e460. doi: 10.1038/emm.2017.301.
Rheumatoid arthritis (RA) is a chronic autoimmune disease that typically results in strong inflammation and bone destruction in the joints. It is generally known that the pathogenesis of RA is linked to cardiovascular and periodontal diseases. Though rheumatoid arthritis and periodontitis share many pathologic features such as a perpetual inflammation and bone destruction, the precise mechanism underlying a link between these two diseases has not been fully elucidated. Collagen-induced arthritis (CIA) mice were orally infected with Porphyromonas gingivalis (Pg) or Pg preincubated with an anti-FimA antibody (FimA Ab) specific for fimbriae that are flexible appendages on the cell surface. Pg-infected CIA mice showed oral microbiota disruption and increased alveolar bone loss and had synovitis and joint bone destruction. However, preincubation with FimA Ab led to a significant reduction in the severity of both oral disease and arthritis. Moreover, FimA Ab attenuated bacterial attachment and aggregation on human gingival and rheumatoid arthritis synovial fibroblasts. In addition, we discovered bacteria may utilize dendritic cells, macrophages and neutrophils to migrate into the joints of CIA mice. These results suggest that disrupting Pg fimbriae function by FimA Ab ameliorates RA.
类风湿关节炎（RA）是一种慢性自身免疫性疾病，通常会导致关节强烈炎症和骨破坏。一般认为，RA 的发病机制与心血管疾病和牙周病有关。虽然类风湿关节炎和牙周炎有许多共同的病理特征，如持续的炎症和骨破坏，但这两种疾病之间联系的确切机制尚未完全阐明。胶原诱导性关节炎（CIA）小鼠经口感染牙龈卟啉单胞菌（Pg）或用针对细胞表面的可弯曲附属物菌毛的抗 FimA 抗体（FimA Ab）预先孵育的 Pg。Pg 感染的 CIA 小鼠表现出口腔微生物群失调和牙槽骨丢失增加，并伴有滑膜炎和关节骨破坏。然而，用 FimA Ab 预先孵育导致口腔疾病和关节炎的严重程度显著降低。此外，FimA Ab 减弱了细菌在人牙龈和类风湿关节炎滑膜成纤维细胞上的附着和聚集。此外，我们发现细菌可能利用树突状细胞、巨噬细胞和中性粒细胞迁移到 CIA 小鼠的关节中。这些结果表明，通过 FimA Ab 破坏 Pg 菌毛功能可改善 RA。
