Hu Weiqi, Chen Shuoling, Zou Xianghui, Chen Yan, Luo Jiayu, Zhong Peiliang, Ma Dandan
Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, No 366 Jiangnan Avenue South, Guangzhou, Guangdong Province 510280, China.
Department of Pediatric Dentistry, Stomatological Hospital, School of Stomatology, Southern Medical University, No 366 Jiangnan Avenue South, Guangzhou, Guangdong Province 510280, China.
J Adv Res. 2024 Aug 17. doi: 10.1016/j.jare.2024.08.019.
Homeostasis is a state of self-regulation and dynamic equilibrium, maintaining the good physiological functions of each system in living organisms. In the oral cavity, the interaction between the host and the oral microbiome forms oral microbial homeostasis. Physiological bone remodeling and renewal can occur under the maintenance of oral microbial homeostasis. The imbalance of bone homeostasis is a key mechanism leading to the occurrence of systemic bone-related diseases. Considering the importance of oral microbial homeostasis in the maintenance of bone homeostasis, it still lacks a complete understanding of the relationship between oral microbiome, periodontal disease and systemic bone-related diseases.
This review focuses on the homeostatic changes, pathogenic routes and potential mechanisms in the oral microbiome in periodontal disease and systemic bone-related diseases such as rheumatoid arthritis, osteoarthritis, osteoporosis and osteomyelitis. Additionally, this review discusses oral microbiome-based diagnostic approaches and explores probiotics, mesenchymal stem cells, and oral microbiome transplantation as promising treatment strategies.
This review highlights the association between oral microbial homeostasis imbalance and systemic bone-related diseases, and highlights the possibility of remodeling oral microbial homeostasis for the prevention and treatment of systemic bone-related diseases.
稳态是一种自我调节和动态平衡的状态，维持着生物体各系统的良好生理功能。在口腔中，宿主与口腔微生物群之间的相互作用形成了口腔微生物稳态。在口腔微生物稳态的维持下，生理状态的骨重塑和更新得以发生。骨稳态失衡是导致全身性骨相关疾病发生的关键机制。鉴于口腔微生物稳态在维持骨稳态中的重要性，目前仍缺乏对口腔微生物群、牙周病与全身性骨相关疾病之间关系的全面认识。
本综述聚焦于牙周病以及类风湿关节炎、骨关节炎、骨质疏松症和骨髓炎等全身性骨相关疾病中口腔微生物群的稳态变化、致病途径和潜在机制。此外，本综述还讨论了基于口腔微生物群的诊断方法，并探讨了益生菌、间充质干细胞和口腔微生物群移植作为有前景的治疗策略。
本综述强调了口腔微生物稳态失衡与全身性骨相关疾病之间的关联，并突出了重塑口腔微生物稳态以预防和治疗全身性骨相关疾病的可能性。
