The -2518 A/G polymorphism of the monocyte chemoattractant protein-1 as a candidate genetic predisposition factor for secondary myelofibrosis and biomarker of disease severity.
作者信息
Masselli Elena, Carubbi Cecilia, Cambò Benedetta, Pozzi Giulia, Gobbi Giuliana, Mirandola Prisco, Follini Elena, Pagliaro Luca, Di Marcantonio Daniela, Bonatti Francesco, Percesepe Antonio, Sykes Stephen M, Aversa Franco, Vitale Marco
机构信息
Department of Medicine and Surgery, Unit of Biomedical, Biotechnological and Translational Sciences (S.Bi.Bi.T.), University of Parma, Parma, Italy.
Department of Medicine and Surgery, Unit of Clinical and Experimental Medicine, Hematology and BMT Unit, University of Parma, Parma, Italy.
出版信息
Leukemia. 2018 Oct;32(10):2266-2270. doi: 10.1038/s41375-018-0088-y. Epub 2018 Mar 6.
Abstract
摘要
相似文献
1
The -2518 A/G polymorphism of the monocyte chemoattractant protein-1 as a candidate genetic predisposition factor for secondary myelofibrosis and biomarker of disease severity.单核细胞趋化蛋白-1的-2518 A/G多态性作为继发性骨髓纤维化的候选遗传易感性因素及疾病严重程度的生物标志物。
Leukemia. 2018 Oct;32(10):2266-2270. doi: 10.1038/s41375-018-0088-y. Epub 2018 Mar 6.
2
Association of the -2518 A/G Polymorphism of MCP-1 with Breast Cancer in Punjab, North-West India.印度西北部旁遮普邦MCP - 1基因 -2518 A/G多态性与乳腺癌的关联
Asian Pac J Cancer Prev. 2015;16(16):7243-8. doi: 10.7314/apjcp.2015.16.16.7243.
3
4
Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy.单核细胞趋化蛋白 1 基因多态性与非家族性特发性扩张型心肌病易感性的关联。
J Cardiol. 2009 Aug;54(1):66-70. doi: 10.1016/j.jjcc.2009.04.001. Epub 2009 May 13.
5
The MCP-1 -2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population.MCP - 1 -2518（A到G）单核苷酸多态性与捷克人群中的心肌梗死无关。
Int J Immunogenet. 2005 Oct;32(5):315-8. doi: 10.1111/j.1744-313X.2005.00530.x.
6
Analysis of the monocyte chemoattractant protein 1 -2518 promoter polymorphism in Korean patients with alopecia areata.韩国斑秃患者单核细胞趋化蛋白1 - 2518启动子多态性分析
J Korean Med Sci. 2006 Feb;21(1):90-4. doi: 10.3346/jkms.2006.21.1.90.
7
No association of the MCP-1 promoter A-2518G polymorphism with bipolar disorder in the Korean population.在韩国人群中，MCP - 1启动子A - 2518G多态性与双相情感障碍无关联。
Neurosci Lett. 2007 Oct 29;427(1):1-5. doi: 10.1016/j.neulet.2007.04.038. Epub 2007 Apr 21.
8
Association of the MCP-1 -2518 A/G polymorphism and no association of its receptor CCR2 -64 V/I polymorphism with lupus nephritis.MCP-1-2518A/G 多态性与狼疮肾炎相关，而其受体 CCR2-64V/I 多态性与狼疮肾炎无关。
J Rheumatol. 2010 Apr;37(4):776-82. doi: 10.3899/jrheum.090681. Epub 2010 Mar 15.
9
The ERCC2 Gln/Gln polymorphism at codon 751 is not associated with leukaemic transformation in primary myelofibrosis.
Br J Haematol. 2013 Aug;162(3):424-7. doi: 10.1111/bjh.12376. Epub 2013 May 14.
10
Monocyte chemoattractant protein (MCP-1) A-2518G gene polymorphism in stroke patients with different comorbidities.载脂蛋白 E 基因多态性与缺血性脑卒中患者颈动脉粥样硬化斑块稳定性的相关性
Clin Biochem. 2010 Dec;43(18):1421-6. doi: 10.1016/j.clinbiochem.2010.09.011. Epub 2010 Sep 27.
引用本文的文献
1
The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases.CCL2/CCR2信号轴在炎症性和纤维化疾病中的作用及治疗靶点
Front Immunol. 2025 Jan 9;15:1497026. doi: 10.3389/fimmu.2024.1497026. eCollection 2024.
2
Functionally Relevant Cytokine/Receptor Axes in Myelofibrosis.骨髓纤维化中功能相关的细胞因子/受体轴
Biomedicines. 2023 Sep 5;11(9):2462. doi: 10.3390/biomedicines11092462.
3
Molecular Studies for the Early Detection of Philadelphia-Negative Myeloproliferative Neoplasms.用于早期检测费城阴性骨髓增殖性肿瘤的分子研究。
Int J Mol Sci. 2023 Aug 11;24(16):12700. doi: 10.3390/ijms241612700.
4
Tracking fibrosis in myeloproliferative neoplasms by CCR2 expression on CD34 cells.通过CD34细胞上CCR2的表达追踪骨髓增殖性肿瘤中的纤维化
Front Oncol. 2022 Aug 22;12:980379. doi: 10.3389/fonc.2022.980379. eCollection 2022.
5
Towards a Personalized Definition of Prognosis in Philadelphia-Negative Myeloproliferative Neoplasms.迈向个体化定义费城阴性骨髓增殖性肿瘤的预后。
Curr Hematol Malig Rep. 2022 Oct;17(5):127-139. doi: 10.1007/s11899-022-00672-6. Epub 2022 Sep 1.
6
Cytokine pathway variants modulate platelet production: IFNA16 is a thrombocytosis susceptibility locus in humans.细胞因子途径变异可调节血小板生成：IFNA16 是人类血小板增多症的易感基因座。
Blood Adv. 2022 Aug 23;6(16):4884-4900. doi: 10.1182/bloodadvances.2021005648.
7
CCL2 rs1024611Gene Polymorphism in Philadelphia-Negative Myeloproliferative Neoplasms.CCL2 rs1024611 基因多态性与费城染色体阴性骨髓增殖性肿瘤。
Genes (Basel). 2022 Mar 10;13(3):492. doi: 10.3390/genes13030492.
8
Predictive Value of miR-146a rs2431697 Polymorphism to Myelofibrosis Progression in Patients with Myeloproliferative Neoplasm.miR-146a rs2431697 多态性对骨髓增生性肿瘤患者骨髓纤维化进展的预测价值。
Asian Pac J Cancer Prev. 2021 Nov 1;22(11):3585-3589. doi: 10.31557/APJCP.2021.22.11.3585.
9
Polymorphism Contributes to -Mutation Susceptibility and Is Associated with Low Risk of Deep Vein Thrombosis in Primary Myelofibrosis.多态性与基因突变易感性相关，并与原发性骨髓纤维化患者深静脉血栓形成的低风险有关。
TH Open. 2021 Nov 9;5(4):e513-e520. doi: 10.1055/s-0041-1739293. eCollection 2021 Oct.
10
The Genetic Makeup of Myeloproliferative Neoplasms: Role of Germline Variants in Defining Disease Risk, Phenotypic Diversity and Outcome.骨髓增殖性肿瘤的遗传学特征：胚系变异在定义疾病风险、表型多样性和预后中的作用。
Cells. 2021 Sep 29;10(10):2597. doi: 10.3390/cells10102597.
本文引用的文献
1
Platelet expression of PKCepsilon oncoprotein in myelofibrosis is associated with disease severity and thrombotic risk.骨髓纤维化中蛋白激酶Cε癌蛋白的血小板表达与疾病严重程度和血栓形成风险相关。
Ann Transl Med. 2017 Jul;5(13):273. doi: 10.21037/atm.2017.06.22.
2
Inflammation and myeloproliferative neoplasms.炎症和骨髓增殖性肿瘤。
J Autoimmun. 2017 Dec;85:58-63. doi: 10.1016/j.jaut.2017.06.010. Epub 2017 Jun 30.
3
Presentation and outcome of patients with 2016 WHO diagnosis of prefibrotic and overt primary myelofibrosis.2016 年 WHO 诊断的前纤维化和显性原发性骨髓纤维化患者的表现和转归。
Blood. 2017 Jun 15;129(24):3227-3236. doi: 10.1182/blood-2017-01-761999. Epub 2017 Mar 28.
4
Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms.经典骨髓增殖性肿瘤的遗传学基础和分子病理生理学。
Blood. 2017 Feb 9;129(6):667-679. doi: 10.1182/blood-2016-10-695940. Epub 2016 Dec 27.
5
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.2016 年版世界卫生组织髓系肿瘤和急性白血病分类。
Blood. 2016 May 19;127(20):2391-405. doi: 10.1182/blood-2016-03-643544. Epub 2016 Apr 11.
6
Molecular biomarkers of thrombosis in myeloproliferative neoplasms.骨髓增殖性肿瘤中血栓形成的分子生物标志物。
Thromb Res. 2016 Apr;140 Suppl 1:S71-5. doi: 10.1016/S0049-3848(16)30102-5.
7
MPNs as Inflammatory Diseases: The Evidence, Consequences, and Perspectives.骨髓增殖性肿瘤作为炎症性疾病：证据、后果及展望
Mediators Inflamm. 2015;2015:102476. doi: 10.1155/2015/102476. Epub 2015 Oct 28.
8
Circulating Cytokine Levels as Markers of Inflammation in Philadelphia Negative Myeloproliferative Neoplasms: Diagnostic and Prognostic Interest.循环细胞因子水平作为费城阴性骨髓增殖性肿瘤炎症标志物的诊断和预后意义
Mediators Inflamm. 2015;2015:670580. doi: 10.1155/2015/670580. Epub 2015 Oct 7.
9
Protein kinase Cɛ inhibition restores megakaryocytic differentiation of hematopoietic progenitors from primary myelofibrosis patients.蛋白激酶 Cɛ 抑制可恢复原发性骨髓纤维化患者造血祖细胞的巨核细胞分化。
Leukemia. 2015 Nov;29(11):2192-201. doi: 10.1038/leu.2015.150. Epub 2015 Jun 19.
10
Chronic inflammation as a promotor of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?慢性炎症作为原发性血小板增多症、真性红细胞增多症和骨髓纤维化中突变的促进因素。一种人类炎症模型与癌症发展有关？
Leuk Res. 2013 Feb;37(2):214-20. doi: 10.1016/j.leukres.2012.10.020. Epub 2012 Nov 20.
Zotero 插件