Department of Natural Medicines, Daiichi University of Pharmacy, 22-1 Tamagawa-cho, Minami-ku, Fukuoka, 815-8511, Japan.
J Nat Med. 2018 Jun;72(3):798-802. doi: 10.1007/s11418-018-1206-x. Epub 2018 Mar 22.
Vanilla flavour is familiar to consumers through foods, cosmetics, household products and some medicines. Vanilla flavouring agents typically contain vanillin or its analogue ethyl vanillin. Our previous study revealed that the inhalation of eugenol, which contains a vanillyl group, has an appetite-enhancing effect, and the inhalation of aroma compounds containing the vanillyl group or its analogues led to increased food intake in mice. Here, we found that vanillin, ethyl vanillin and eugenol showed appetite-enhancing effects, whereas isoeugenol and safrole did not. These results suggest that the appetite-enhancing effects could be attributable to the vanillyl group and could be affected by the position of the double bond in the aliphatic chain. Furthermore, the results of intraperitoneal administration of eugenol and vanillin suggest that their appetite-enhancing effects could occur via stimulation of olfactory receptors.
香草味通过食品、化妆品、家庭用品和一些药品为消费者所熟悉。香草调味剂通常含有香草醛或其类似物乙基香草醛。我们之前的研究表明，含有香草基的丁香酚的吸入具有增强食欲的作用，并且吸入含有香草基或其类似物的香气化合物会导致小鼠食物摄入量增加。在这里，我们发现香草醛、乙基香草醛和丁香酚具有增强食欲的作用，而异丁香酚和黄樟素则没有。这些结果表明，食欲增强作用可能归因于香草基，并且可能受到脂肪链中双键位置的影响。此外，丁香酚和香草醛腹腔内给药的结果表明，它们的食欲增强作用可能通过刺激嗅觉受体发生。
