Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
Department of Cardiology, Academic Hospital Paramaribo, Paramaribo, Suriname.
J Clin Hypertens (Greenwich). 2018 Apr;20(4):718-726. doi: 10.1111/jch.13253. Epub 2018 Mar 22.
Women with fibroids have a notably high hypertension risk. However, adjusted data regarding other cardiovascular disease (CVD) risk factors are scarce. In this cross-sectional study, CVD risk factors, hemodynamic parameters, and asymptomatic organ damage were analyzed between women with uterine fibroids and controls in a multi-ethnic population. In total, 104 women with self-reported fibroids and 624 controls were included. Women with fibroids had significantly higher odds to have hypertension (OR 3.4; 95% CI 2.2-5.2), diabetes (1.7; 1.0-2.9), and hypercholesterolemia (1.8; 1.1-3.2). After adjustment for confounders, only the odds ratio for hypertension was significant (1.8; 1.1-3.1). Asymptomatic organ damage occurred significantly more often in women with fibroids (66.7%; 95% CI 55.8%-77.6% vs 42.9%; 38.0-47.8 in controls), especially in the younger age group (respectively 48.5%; 31.1%-65.9% vs 22.1%; 17.0-27.2). In this study, women with fibroids had a remarkably high hypertension risk compared to controls, with more asymptomatic organ damage, in particular young women.
患有子宫肌瘤的女性高血压风险显著升高。然而，关于其他心血管疾病（CVD）风险因素的调整数据却很少。在这项多民族人群的横断面研究中，分析了患有子宫肌瘤的女性和对照组之间 CVD 风险因素、血液动力学参数和无症状器官损伤。共纳入了 104 名自述患有子宫肌瘤的女性和 624 名对照组。患有子宫肌瘤的女性患高血压（OR 3.4；95%CI 2.2-5.2）、糖尿病（1.7；1.0-2.9）和高胆固醇血症（1.8；1.1-3.2）的几率显著更高。在调整混杂因素后，仅高血压的比值比有显著意义（1.8；1.1-3.1）。患有子宫肌瘤的女性无症状器官损伤的发生率显著更高（66.7%；95%CI 55.8%-77.6% vs 42.9%；38.0-47.8），尤其是在年轻组（分别为 48.5%；31.1%-65.9% vs 22.1%；17.0-27.2）。在这项研究中，与对照组相比，患有子宫肌瘤的女性高血压风险显著升高，尤其是年轻女性，无症状器官损伤更多。
