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探索心血管健康:苏里南的健康生活(HELISUR)研究。一项横断面研究方案。

Exploring cardiovascular health: the Healthy Life in Suriname (HELISUR) study. A protocol of a cross-sectional study.

作者信息

Diemer Frederieke S, Aartman Jet Q, Karamat Fares A, Baldew Sergio M, Jarbandhan Ameerani V, van Montfrans Gert A, Oehlers Glenn P, Brewster Lizzy M

机构信息

Department of Cardiology, Academic Hospital Paramaribo, Paramaribo, Suriname Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

出版信息

BMJ Open. 2014 Dec 23;4(12):e006380. doi: 10.1136/bmjopen-2014-006380.

Abstract

INTRODUCTION

Obesity, hypertension and diabetes are on a dramatic rise in low-income and middle-income countries, and this foretells an overwhelming increase in chronic disease burden from cardiovascular disease. Therefore, rapid action should be taken through preventive population-based programmes. However, in these regions, data on the population distribution of cardiovascular risk factors, and of intermediate and final end points for cardiovascular disease are scarce. The Healthy Life in Suriname (HELISUR) study is a cardiovascular population study in Suriname, which is part of the Caribbean Community. The HELISUR study is dedicated to provide data on risk factors and prevalent cardiovascular disease in the multiethnic population, which is mainly of African and Asian descent.

METHODS AND ANALYSIS

In a cross-sectional, observational population-based setting, a random representative sample of 1800 citizens aged between 18 and 70 years will be selected using a cluster household sampling method. Self-reported demographic, socioeconomic and (cardiovascular) health-related data will be collected. Physical examination will include the assessment of cardiovascular risk factors and prevalent cardiovascular disease. In addition, we will study cardiovascular haemodynamics non-invasively, as a novel intermediate outcome. Finally, fasting blood and overnight urine samples will be collected to monitor cardiometabolic risk factors. The main outcome will be descriptive in reporting the prevalence of risk factors and measures of (sub) clinical end organ damage, stratified for ethnicity and sex-age groups.

ETHICS AND DISSEMINATION

Ethical approval has been obtained from the State Secretary of Health. Data analysis and manuscript submission are scheduled for 2016. Findings will be disseminated in peer-reviewed journals, and at national, regional and international scientific meetings. Importantly, data will be presented to Surinamese policymakers and healthcare workers, to develop preventive strategies to combat the rapid rise of cardiovascular disease.

摘要

引言

肥胖、高血压和糖尿病在低收入和中等收入国家正急剧增加,这预示着心血管疾病导致的慢性病负担将大幅上升。因此,应通过基于人群的预防项目迅速采取行动。然而,在这些地区,关于心血管危险因素的人群分布以及心血管疾病的中间和最终终点的数据稀缺。苏里南健康生活(HELISUR)研究是苏里南的一项心血管疾病人群研究,苏里南是加勒比共同体的一部分。HELISUR研究致力于提供关于多民族人群(主要是非洲和亚洲血统)中危险因素和心血管疾病患病率的数据。

方法与分析

在基于人群的横断面观察性研究中,将采用整群家庭抽样方法从1800名年龄在18至70岁之间的公民中随机抽取具有代表性的样本。将收集自我报告的人口统计学、社会经济和(心血管)健康相关数据。体格检查将包括对心血管危险因素和心血管疾病患病率的评估。此外,作为一种新的中间结局,我们将以非侵入性方式研究心血管血液动力学。最后,将采集空腹血液和过夜尿液样本以监测心脏代谢危险因素。主要结局将是描述性的,报告危险因素的患病率以及(亚)临床终末器官损害的指标,并按种族和性别 - 年龄组进行分层。

伦理与传播

已获得卫生国务秘书的伦理批准。数据分析和稿件提交计划于2016年进行。研究结果将在同行评审期刊以及国家、地区和国际科学会议上发表。重要的是,将向苏里南政策制定者和医护人员展示数据,以制定预防策略来应对心血管疾病的快速上升。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86e8/4275662/55090582427e/bmjopen2014006380f01.jpg

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