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从侵袭性葡萄胎和绒毛膜癌患者尿液中纯化得到的人绒毛膜促性腺激素的天冬酰胺连接糖链中发现的结构差异。

Structural differences found in the asparagine-linked sugar chains of human chorionic gonadotropins purified from the urine of patients with invasive mole and with choriocarcinoma.

作者信息

Endo T, Nishimura R, Kawano T, Mochizuki M, Kobata A

出版信息

Cancer Res. 1987 Oct 1;47(19):5242-5.

PMID:2957051
Abstract

Paper electrophoresis of the oligosaccharide fraction obtained by hydrazinolysis of human chorionic gonadotropin (HCG), which was purified from the urine of two patients with invasive mole, gave fractionation patterns different from those of normal and hydatidiform mole HCGs. Structural study of the oligosaccharides in each fraction revealed that the triantennary complex-type asparagine-linked sugar chains, specifically found in choriocarcinoma HCGs, were included in the two HCG samples. However, the unusual biantennary complex type sugar chains, which are also specific for the tumor HCGs, were not detected at all. This result indicated that abnormal expression of N-acetylglucosaminyl-transferase IV during the development of choriocarcinoma occurs in two steps: (a) ectopic expression of the regular N-acetylglucosaminyltransferase IV; and (b) modification of the substrate specificity of the enzyme.

摘要

从两名侵袭性葡萄胎患者尿液中纯化得到的人绒毛膜促性腺激素(HCG)经肼解得到的寡糖部分进行纸电泳,其分级模式与正常和葡萄胎HCG的不同。对各部分寡糖的结构研究表明,在绒毛膜癌HCG中特有的三触角复合型天冬酰胺连接糖链包含在这两个HCG样本中。然而,同样为肿瘤HCG所特有的异常双触角复合型糖链却完全未被检测到。这一结果表明,绒毛膜癌发生过程中N-乙酰葡糖胺转移酶IV的异常表达分两步进行:(a)正常N-乙酰葡糖胺转移酶IV的异位表达;(b)该酶底物特异性的改变。

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