Suppr超能文献

使用稳定分布来描述质子铅笔束。

Using stable distributions to characterize proton pencil beams.

机构信息

CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.

Dept of Haematology/Oncology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

出版信息

Med Phys. 2018 May;45(5):2278-2288. doi: 10.1002/mp.12876. Epub 2018 Apr 15.

Abstract

PURPOSE

To introduce and evaluate the use of stable distributions as a methodology to quantify the behavior of proton pencil beams in a medium.

METHODS

The proton pencil beams of a clinically commissioned proton treatment facility are replicated in a Monte Carlo simulation system (FLUKA). For each available energy, the beam deposition in water medium is characterized by the dose deposition. Using a stable distribution methodology, each beam with a nominal energy E is characterized by the lateral spread at depth z: S(z; α, γ, E) and a total energy deposition I (z, E). The parameter α describes the tailedness of the distributions, while γ is used to scale the size of the function. The beams can then be described completely by a function of the variation of the parameters with depth.

RESULTS

Quantitatively, the fit of the stable distributions, compared to those implemented in some standard treatment planning systems, are equivalent for all but the highest energies (i.e., 230 MeV/u). The decrease in goodness of fit makes this methodology comparable to a double Gaussian approach. The introduction of restricted linear combinations of stable distributions also resolves that particular case. More importantly, the meta-parameterization (i.e., the description of the dose deposition by only providing the fitted parameters) allows for interpolation of nonmeasured data. In the case of the clinical commissioning data used in this paper, it was possible to only commission one out of five nominal energies to obtain a viable dataset, valid for all energies. An additional parameter β allows to describe asymmetric beam profiles as well.

CONCLUSIONS

Stable distributions are intrinsically suited to describe proton pencil beams in a medium and provide a tool to quantify the propagation of proton beams in a medium.

摘要

目的

介绍并评估稳定分布在量化质子束在介质中行为的方法中的应用。

方法

临床委托质子治疗设施中的质子铅笔束在蒙特卡罗模拟系统(FLUKA)中复制。对于每个可用能量,通过剂量沉积来描述水介质中的束沉积。使用稳定分布方法,每个标称能量为 E 的束由深度 z 处的横向扩展 S(z; α, γ, E)和总能量沉积 I (z, E)来描述。参数 α 描述分布的长尾性,而 γ 用于缩放函数的大小。然后,这些束可以通过参数随深度变化的函数来完全描述。

结果

从定量角度来看,与某些标准治疗计划系统中实施的分布相比,稳定分布的拟合在所有能量下(即 230 MeV/u)都是等效的。拟合度的降低使得这种方法与双高斯方法相当。稳定分布的受限线性组合的引入也解决了这种特殊情况。更重要的是,元参数化(即通过仅提供拟合参数来描述剂量沉积)允许对未测量的数据进行插值。在本文中使用的临床委托数据的情况下,仅委托五个标称能量中的一个就可以获得可行的数据集,该数据集对所有能量都有效。附加参数 β 允许描述非对称束轮廓。

结论

稳定分布本质上适合描述介质中的质子铅笔束,并提供了一种量化质子束在介质中传播的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46dc/6571675/1f7014473568/MP-45-2278-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验