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急性呼吸道感染与 25-羟维生素 D 浓度：系统评价与荟萃分析。

Acute Respiratory Tract Infection and 25-Hydroxyvitamin D Concentration: A Systematic Review and Meta-Analysis.

机构信息

Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QL 4006, Australia.

School of Public Health, The University of Queensland, Herston, QL 4006, Australia.

出版信息

Int J Environ Res Public Health. 2019 Aug 21;16(17):3020. doi: 10.3390/ijerph16173020.

DOI:10.3390/ijerph16173020
PMID:31438516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6747229/
Abstract

Observational studies and randomised controlled studies suggest that vitamin D plays a role in the prevention of acute respiratory tract infection (ARTI); however, findings are inconsistent and the optimal serum 25-hydroxyvitamin D (25(OH)D) concentration remains unclear. To review the link between 25(OH)D concentration and ARTI, we searched PubMed and EMBASE databases to identify observational studies reporting the association between 25(OH)D concentration and risk or severity of ARTI. We used random-effects meta-analysis to pool findings across studies. Twenty-four studies were included in the review, 14 were included in the meta-analysis of ARTI risk and five in the meta-analysis of severity. Serum 25(OH)D concentration was inversely associated with risk and severity of ARTI; pooled odds ratios (95% confidence interval) were 1.83 (1.42-2.37) and 2.46 (1.65-3.66), respectively, comparing the lowest with the highest 25(OH)D category. For each 10 nmol/L decrease in 25(OH)D concentration, the odds of ARTI increased by 1.02 (0.97-1.07). This was a non-linear trend, with the sharpest increase in risk of ARTI occurring at 25(OH)D concentration < 37.5 nmol/L. In conclusion, there is an inverse non-linear association between 25(OH)D concentration and ARTI.

摘要

观察性研究和随机对照研究表明，维生素 D 在预防急性呼吸道感染 (ARTI) 中发挥作用；然而，研究结果不一致，最佳血清 25-羟维生素 D（25(OH)D）浓度仍不清楚。为了综述 25(OH)D 浓度与 ARTI 之间的联系，我们检索了 PubMed 和 EMBASE 数据库，以确定报告 25(OH)D 浓度与 ARTI 风险或严重程度之间关联的观察性研究。我们使用随机效应荟萃分析来汇总研究结果。综述纳入了 24 项研究，其中 14 项研究纳入了 ARTI 风险的荟萃分析，5 项研究纳入了严重程度的荟萃分析。血清 25(OH)D 浓度与 ARTI 的风险和严重程度呈负相关；最低与最高 25(OH)D 类别相比，汇总的优势比（95%置信区间）分别为 1.83（1.42-2.37）和 2.46（1.65-3.66）。25(OH)D 浓度每降低 10 nmol/L，ARTI 的几率增加 1.02（0.97-1.07）。这是一种非线性趋势，25(OH)D 浓度<37.5 nmol/L 时 ARTI 风险增加最为明显。总之，25(OH)D 浓度与 ARTI 之间存在负向非线性关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/8d6b3b80fa1d/ijerph-16-03020-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/d12e0043e868/ijerph-16-03020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/2e5768984107/ijerph-16-03020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/898dc096234f/ijerph-16-03020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/8a1bd62f76f6/ijerph-16-03020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/8279e528fa64/ijerph-16-03020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/b1c0bb127e1c/ijerph-16-03020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/8d6b3b80fa1d/ijerph-16-03020-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/d12e0043e868/ijerph-16-03020-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/2e5768984107/ijerph-16-03020-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/898dc096234f/ijerph-16-03020-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/8a1bd62f76f6/ijerph-16-03020-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/8279e528fa64/ijerph-16-03020-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/b1c0bb127e1c/ijerph-16-03020-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0342/6747229/8d6b3b80fa1d/ijerph-16-03020-g007.jpg

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