From the Department of Functional Neurosurgery (H.A.R., T.Z.A., J.J.F., A.L.G.) and Nuffield Department of Surgical Sciences (H.A.R., T.Z.A., J.J.F., A.L.G.), John Radcliffe Hospital, Oxford; and Department of Neurosurgery (H.A.R.), Derriford Hospital, Plymouth, UK.
Neurology. 2018 Apr 24;90(17):e1530-e1534. doi: 10.1212/WNL.0000000000005355. Epub 2018 Mar 23.
To investigate the role of beta oscillations in urinary voiding and their association with lower urinary tract symptoms in Parkinson disease (PD).
We used surgically implanted deep brain stimulation electrodes to record local field potential signals from the subthalamic nucleus (STN) and globus pallidus interna (GPi) of patients with PD during urinary voiding. Five patients with STN electrodes and 5 patients with GPi electrodes were tested. We also explored correlations between beta oscillatory power and urinary symptoms assessed by the International Consultation on Incontinence Lower Urinary Tract Symptoms questionnaire.
Beta suppression occurred during urinary voiding in the GPi ( < 0.05) but not the STN. Furthermore, the beta signal in the GPi during voiding correlated significantly with severity of incontinence and urinary frequency ( < 0.05).
In this study, we have demonstrated that local field potentials can provide information about the neural control of the bladder. Our findings suggest that the GPi is implicated in the process of urinary voiding and that its mechanism of action is linked to signals in the beta frequency band. Moreover, our correlational analyses show that beta oscillations may be implicated more generally in the pathophysiology of lower urinary tract symptoms in PD.
研究β振荡在排尿中的作用及其与帕金森病（PD）下尿路症状的关系。
我们使用植入的深部脑刺激电极记录 PD 患者排尿过程中的丘脑底核（STN）和内苍白球（GPi）的局部场电位信号。对 5 例 STN 电极患者和 5 例 GPi 电极患者进行了测试。我们还探索了β振荡功率与国际尿失禁咨询委员会下尿路症状问卷评估的尿症状之间的相关性。
在 GPi 中，β抑制发生在排尿过程中（<0.05），而在 STN 中则没有。此外，在 GPi 中，排尿过程中的β信号与失禁严重程度和排尿频率显著相关（<0.05）。
在这项研究中，我们已经证明局部场电位可以提供有关膀胱神经控制的信息。我们的研究结果表明，GPi 参与了排尿过程，其作用机制与β频带的信号有关。此外，我们的相关分析表明，β振荡可能更普遍地与 PD 下尿路症状的病理生理学有关。
