日本林奇综合征患者饮酒与结直肠癌早发风险：日本结直肠癌学会开展的一项横断面研究
Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum.
作者信息
Miguchi Masashi, Hinoi Takao, Tanakaya Kohji, Yamaguchi Tatsuro, Furukawa Yoichi, Yoshida Teruhiko, Tamura Kazuo, Sugano Kokichi, Ishioka Chikashi, Matsubara Nagahide, Tomita Naohiro, Arai Masami, Ishikawa Hideki, Hirata Keiji, Saida Yoshihisa, Ishida Hideyuki, Sugihara Kenichi
机构信息
Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, 7348551, Hiroshima, Japan.
Department of Surgery, Iwakuni Clinical Center, Yamaguchi, Japan.
出版信息
Surg Today. 2018 Aug;48(8):810-814. doi: 10.1007/s00595-018-1654-7. Epub 2018 Mar 24.
We conducted this study to establish whether drinking alcohol alters the risk of early-onset colorectal cancer (CRC) in Japanese patients with Lynch syndrome (LS). The subjects were 66 LS patients with pathogenic mutation of mismatch repair genes (MLH1, MSH2, and MSH6) from the nationwide Japanese retrospective multicenter study. Cox proportional hazards modeling was used to investigate the factors correlating with early-onset CRC diagnosis, using clinical data such as gender, tobacco use, alcohol consumption, body mass index, gene mutation (MLH1, MSH2 vs MSH6), and family cancer history. Alcohol was significantly correlated with an increased risk of early-onset CRC [HR 2.44, 95% CI 1.13-5.16 (p = 0.02)], but tobacco use was not [HR 0.8, 95%CI 0.38-1.62 (p = 0.53)]. These findings suggest that alcohol consumption is correlated with an earlier onset of CRC in Japanese patients with LS.
我们开展这项研究是为了确定饮酒是否会改变日本林奇综合征（LS）患者早发性结直肠癌（CRC）的风险。研究对象来自日本全国性回顾性多中心研究中的66例错配修复基因（MLH1、MSH2和MSH6）发生致病性突变的LS患者。采用Cox比例风险模型，利用性别、吸烟、饮酒、体重指数、基因突变（MLH1、MSH2与MSH6）和家族癌症病史等临床数据，研究与早发性CRC诊断相关的因素。饮酒与早发性CRC风险增加显著相关[风险比（HR）2.44，95%置信区间（CI）1.13 - 5.16（p = 0.02）]，但吸烟则不然[HR 0.8，95%CI 0.38 - 1.62（p = 0.53）]。这些发现表明，饮酒与日本LS患者CRC发病较早相关。
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