Zhang Li, Bei Ho Pan, Piao Yun, Wang Yufeng, Yang Mo, Zhao Xin
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Department of Chemistry, The University of Hong Kong, Pokfulum Road, Hong Kong, China.
Chemphyschem. 2018 Aug 17;19(16):1956-1964. doi: 10.1002/cphc.201800018. Epub 2018 Apr 14.
Mesoporous silica nanoparticles (MSNs) have been demonstrated to be one of the most promising drug-delivery systems (DDSs) to transport a variety of drugs/biomolecules. Functionalization of MSN surfaces with responsive polymer brushes leads to intelligent and controllable drug-delivery properties, that is, the encapsulated drugs/biomolecules will only be released upon certain stimuli including pH, temperature, light, enzyme, ultrasound, or redox, thus maximizing their therapeutic efficiency and minimizing side effects. These polymer brushes can also increase the stability and extend the release period of the loaded cargoes. This Minireview presents an overview of recent research progress on stimuli-responsive controlled DDSs based on polymer-brush-grafted MSNs. Utilizing the switching abilities of the grafted responsive polymer brushes, the smart DDSs show great potential for biomedical applications, especially for cancer therapy.
介孔二氧化硅纳米颗粒（MSNs）已被证明是最有前途的药物递送系统（DDSs）之一，可用于运输多种药物/生物分子。用响应性聚合物刷对MSN表面进行功能化可产生智能且可控的药物递送特性，即封装的药物/生物分子仅在特定刺激（包括pH值、温度、光、酶、超声或氧化还原）下才会释放，从而最大限度地提高其治疗效率并最小化副作用。这些聚合物刷还可以提高负载货物的稳定性并延长其释放期。本综述概述了基于聚合物刷接枝的MSNs的刺激响应控制DDSs的最新研究进展。利用接枝的响应性聚合物刷的切换能力，智能DDSs在生物医学应用中显示出巨大潜力，尤其是在癌症治疗方面。
