Liang Shucai, Chang Lulin
Luohe Medical College, Luohe 462002, Henan Province, PR China.
Biomark Med. 2018 Apr;12(4):393-402. doi: 10.2217/bmm-2017-0206. Epub 2018 Mar 26.
To comprehensively evaluate the diagnostic value of serum matrix metalloproteinase-9 (MMP-9) level for colorectal cancer (CRC).
Both of the relationships between MMP-9 level and CRC and the diagnostic value were evaluated from 12 eligible papers.
The high MMP-9 level increased CRC risk. The estimated sensitivity and specificity were 69 and 68%, respectively, which signified that the diagnostic value was medium. Diagnostic odds ratio and the area under the receiver operating characteristic curve suggested MMP-9 level has a moderate diagnostic value in CRC. Additionally, the likelihood matrix indicated MMP-9 levels could be considered as a biomarker for the diagnosis of CRC.
Patients with CRC have elevated MMP-9 levels, which is a potential biomarker for CRC diagnosis.
全面评估血清基质金属蛋白酶-9（MMP-9）水平对结直肠癌（CRC）的诊断价值。
从12篇符合条件的论文中评估MMP-9水平与CRC之间的关系以及诊断价值。
MMP-9水平升高会增加患CRC的风险。估计的敏感性和特异性分别为69%和68%，这表明诊断价值中等。诊断比值比和受试者工作特征曲线下面积表明MMP-9水平在CRC中具有中等诊断价值。此外，似然矩阵表明MMP-9水平可被视为CRC诊断的生物标志物。
CRC患者的MMP-9水平升高，这是CRC诊断的潜在生物标志物。
