间歇性禁食对血脂水平的影响：与饮食和体重减轻相关的评估

Impact of intermittent fasting on the lipid profile: Assessment associated with diet and weight loss.

作者信息

Santos Heitor O, Macedo Rodrigo C O

机构信息

School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil.

University of Santa Cruz do Sul (UNISC), Santa Cruz do Sul, Brazil.

出版信息

Clin Nutr ESPEN. 2018 Apr;24:14-21. doi: 10.1016/j.clnesp.2018.01.002.

DOI:10.1016/j.clnesp.2018.01.002

PMID:29576352

Abstract

Intermittent fasting, whose proposed benefits include the improvement of lipid profile and the body weight loss, has gained considerable scientific and popular repercussion. This review aimed to consolidate studies that analyzed the lipid profile in humans before and after intermittent fasting period through a detailed review; and to propose the physiological mechanism, considering the diet and the body weight loss. Normocaloric and hypocaloric intermittent fasting may be a dietary method to aid in the improvement of the lipid profile in healthy, obese and dyslipidemic men and women by reducing total cholesterol, LDL, triglycerides and increasing HDL levels. However, the majority of studies that analyze the intermittent fasting impacts on the lipid profile and body weight loss are observational based on Ramadan fasting, which lacks large sample and detailed information about diet. Randomized clinical trials with a larger sample size are needed to evaluate the IF effects mainly in patients with dyslipidemia.

摘要

间歇性禁食，其预期益处包括改善血脂状况和减轻体重，已在科学界和大众中引起了相当大的反响。本综述旨在通过详细回顾来整合那些分析人类在间歇性禁食前后血脂状况的研究；并考虑饮食和体重减轻情况，提出其生理机制。正常热量和低热量间歇性禁食可能是一种饮食方法，通过降低总胆固醇、低密度脂蛋白、甘油三酯并提高高密度脂蛋白水平，来帮助改善健康、肥胖和血脂异常的男性和女性的血脂状况。然而，大多数分析间歇性禁食对血脂状况和体重减轻影响的研究都是基于斋月禁食的观察性研究，这类研究缺乏大样本以及关于饮食的详细信息。需要进行更大样本量的随机临床试验，主要是评估间歇性禁食对血脂异常患者的影响。