Dharmadhikari A S, Tandle A L, Jaiswal S V, Sawant V A, Vahia V N, Jog N
Department of Psychiatry, H B T Medical College & Dr R N Cooper Municipal General Hospital, Mumbai, Maharashtra, India.
Department of Electronics & Telecommunication, Mukesh Patel School of Technology, Management & Engineering, NMIMS University, Mumbai, Maharashtra, India.
East Asian Arch Psychiatry. 2018 Mar;28(1):17-22.
Electroencephalography (EEG) has been used extensively to study affective disorders. Quantitative spectral analysis of an EEG scan has been used to assess the biological basis of emotional disorders such as depression as well as to investigate biomarkers of affective disorders. Inter-hemispheric asymmetries in both baseline and stimulus-evoked frequencies (alpha, beta, theta, and delta) are potential biomarkers of depression. The role of frontal alpha asymmetry has been established, but other spectral frequencies such as frontal theta remain elusive. We compared the hemispheric differences in frontal theta power in depressed patients and controls before and during listening to music to study the correlation of frontal theta asymmetry with depression.
To determine whether stimulus-evoked frontal theta asymmetry is a biomarker of depression, we compared 23 patients with mild depression (based on the Hamilton Depression Rating Scale) with 17 age- and sex-matched controls by conducting EEG at rest and after listening to Indian classical music.
In controls without depression, the mean frontal theta power of the left hemisphere and frontal theta asymmetry increased significantly during music listening. In depressed patients, frontal theta asymmetry was reversed during music listening.
Frontal theta asymmetry is a potential biomarker of depression.
脑电图（EEG）已被广泛用于研究情感障碍。脑电图扫描的定量频谱分析已被用于评估诸如抑郁症等情绪障碍的生物学基础，以及研究情感障碍的生物标志物。基线和刺激诱发频率（α、β、θ和δ）的半球间不对称是抑郁症的潜在生物标志物。额叶α不对称的作用已得到证实，但其他频谱频率，如额叶θ，仍然难以捉摸。我们比较了抑郁症患者和对照组在听音乐之前和期间额叶θ功率的半球差异，以研究额叶θ不对称与抑郁症的相关性。
为了确定刺激诱发的额叶θ不对称是否为抑郁症的生物标志物，我们通过在静息状态和听印度古典音乐后进行脑电图，比较了23例轻度抑郁症患者（基于汉密尔顿抑郁量表）和17例年龄和性别匹配的对照组。
在无抑郁症的对照组中，听音乐期间左半球的平均额叶θ功率和额叶θ不对称显著增加。在抑郁症患者中，听音乐期间额叶θ不对称发生逆转。
额叶θ不对称是抑郁症的潜在生物标志物。
