The Affiliated Brain Hospital of Guangzhou Medical University, China.
The Affiliated Brain Hospital of Guangzhou Medical University, China.
J Affect Disord. 2024 Jul 1;356:477-482. doi: 10.1016/j.jad.2024.04.085. Epub 2024 Apr 22.
The prevalence of depressive disorder is increasing due to a variety of factors, which brings a huge strain on individuals, families and society. This study aims to investigate whether there is Frontal Theta Asymmetry (FTA) in depressed patients, and whether FTAs are related to depression severity and cognitive function changes in depressed patients.
Participants who met the inclusion criteria were enrolled in this study. Socio-demographic data of each participant were recorded. Zung's self-rating Depression Scale was used to assess the depression status of participants. P300 was used to evaluate the cognitive function of participants. EEG data from participants were collected by the NeuroScan SynAmps RT EEG system. t-test, Wilcoxon rank-sum test and Chi-square test were used to detect the differences of different variables between the two groups. Multiple linear regression analysis and multiple logistic regression analysis were used to analyze relationships between FTAs in different regions and participants' depression status and cognitive function.
A total of 66 depressed participants and 47 healthy control participants were included in this study. The theta spectral power of the left frontal lobe was slightly stronger than that of the right frontal lobe in the depression group, while the opposite was true in the healthy control group. The FTA in F3/F4 had certain effects on the emergence of depression in participants, the emergence of depression in participants and Changes in cognitive function.
FTAs are helpful to assess the severity of depression and early identify cognitive impairment in patients with depression.
由于多种因素的影响，抑郁障碍的患病率不断增加，给个体、家庭和社会带来了巨大的负担。本研究旨在探讨抑郁患者是否存在额区 theta 不对称（FTA），以及 FTAs 是否与抑郁患者的抑郁严重程度和认知功能变化有关。
符合纳入标准的参与者被纳入本研究。记录每位参与者的社会人口统计学数据。采用zung 氏自评抑郁量表评估参与者的抑郁状况。采用 P300 评估参与者的认知功能。使用 neuroscan synamps rt eeg 系统采集参与者的 EEG 数据。采用 t 检验、wilcoxon 秩和检验和卡方检验比较两组间不同变量的差异。采用多元线性回归分析和多元逻辑回归分析分析不同脑区 FTAs 与参与者抑郁状态和认知功能的关系。
本研究共纳入 66 例抑郁患者和 47 例健康对照者。抑郁组左额区的 theta 频谱功率略强于右额区，而健康对照组则相反。F3/F4 区的 FTA 对参与者出现抑郁、出现抑郁以及认知功能变化有一定影响。
FTAs 有助于评估抑郁的严重程度，并早期识别抑郁患者的认知功能障碍。
