Heravi Farzin, Ahrari Farzaneh, Tanbakuchi Behrad
Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Orthodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Dent Res J (Isfahan). 2018 Mar-Apr;15(2):95-103.
This clinical trial investigated the effectiveness of two remineralizing creams on regression of white spot lesions (WSLs) after orthodontic therapy.
The study included patients with WSLs on their upper anterior teeth who recently completed orthodontic treatment at the Department of Orthodontics of Mashhad Dental School and two private offices. The participants were randomly assigned into three groups by treatment: (1) a 12-week regimen of a cream containing casein phosphopeptide-amorphous calcium phosphate and fluoride (MI Paste Plus); (2) a 12-week regimen of a cream containing hydroxyapatite and fluoride (Remin Pro); and (3) usual home care (control). Thirty-nine patients participated and three withdrew. The main outcomes including area, mineral content, and color of WSLs were measured at enrolment and 4, 8, and 12 weeks later, respectively. Blinding was applied for outcome assessment only. The data were analyzed by analysis of variance and repeated measures analysis at the statistical significance of < 0.05.
Over a 3-month period, the application of both MI Paste Plus and Remin Pro caused significantly greater reduction in area and significantly higher increase in mineral content of WSLs compared to the control group ( < 0.05). The appearance of WSLs improved significantly in both experimental groups ( < 0.05), but not in the control group. No side effect was observed throughout the experiment.
The application of either MI Paste Plus or Remin Pro was effective in reducing the area, increasing the mineral content and improving the appearance of demineralized enamel, indicating that these products could be recommended for managing postorthodontic WSLs.
本临床试验研究了两种再矿化乳膏对正畸治疗后白斑病变（WSLs）消退的有效性。
该研究纳入了在上颌前牙出现WSLs且最近在马什哈德牙科学院正畸科和两家私人诊所完成正畸治疗的患者。参与者按治疗方法随机分为三组：（1）使用含酪蛋白磷酸肽 - 无定形磷酸钙和氟化物的乳膏进行为期12周的治疗方案（MI Paste Plus）；（2）使用含羟基磷灰石和氟化物的乳膏进行为期12周的治疗方案（Remin Pro）；（3）常规家庭护理（对照组）。39名患者参与研究，3名退出。分别在入组时以及4周、8周和12周后测量主要结局，包括WSLs的面积、矿物质含量和颜色。仅在结局评估时采用盲法。数据采用方差分析和重复测量分析进行分析，统计学显著性水平为<0.05。
在3个月的时间里，与对照组相比，使用MI Paste Plus和Remin Pro均使WSLs的面积显著减小，矿物质含量显著增加（<0.05）。两个试验组中WSLs的外观均有显著改善（<0.05），而对照组没有。在整个实验过程中未观察到副作用。
使用MI Paste Plus或Remin Pro均可有效减小脱矿釉质的面积、增加矿物质含量并改善外观，表明这些产品可推荐用于处理正畸后的WSLs。
