De Moraes Carlos Gustavo, Muhammad Hassan, Kaur Khushmit, Wang Diane, Ritch Robert, Hood Donald C
Department of Ophthalmology, Columbia University Medical Center, New York, NY, USA.
Department of Physiology, Biophysics, and Systems Biology, Weill Cornell Medicine, New York, NY, USA.
Transl Vis Sci Technol. 2018 Mar 9;7(2):4. doi: 10.1167/tvst.7.2.4. eCollection 2018 Mar.
We tested the hypothesis that variations in foveal morphology can account for artifacts seen on optical coherence tomography (OCT) retinal ganglion cell (RGC) layer probability maps.
A total of 126 healthy subjects were tested with spectral domain (sd) OCT. Thickness and probability maps of the macular RGC plus inner plexiform layer (RGC+) were obtained with customized software. Macular b-scans were analyzed to derive three foveal anatomic parameters: width, depth, and slope. The distribution of these parameters was compared between eyes with and without circumfoveal artifacts seen in the central 4° of macular RGC+ probability maps.
Of 126 healthy subjects, 12 (9.5%) had an abnormal circumfoveal region (artifact) on RGC+ probability maps. Based upon the normal distribution of the three anatomic parameters, only three of the 12 eyes (25%) fell outside the 95% confidence interval of one or more of the three foveal morphologic parameters. Multivariable logistic regression revealed that the parameter slope was significantly associated with the presence of these artifacts (odds ratio = 0.26; = 0.019). However, the combination of these parameters and age explained only 11% of the total variance of these artifacts.
Fovea morphology, as measured based upon width, depth, and slope, has a minor role in explaining artifacts seen on macular scans. Variations in the distribution of RGC+ thickness that are not reflected in our measures warrant further investigation as potential sources of artifacts.
A small proportion of circumfoveal artifacts seen on RGC+ probability maps can be explained by variations in foveal anatomy.
我们检验了如下假设，即中央凹形态的变化可解释光学相干断层扫描（OCT）视网膜神经节细胞（RGC）层概率图上出现的伪影。
对总共126名健康受试者进行了频域（sd）OCT检测。使用定制软件获取黄斑RGC加内丛状层（RGC+）的厚度和概率图。分析黄斑B扫描以得出三个中央凹解剖参数：宽度、深度和斜率。比较在黄斑RGC+概率图中央4°范围内出现和未出现中心凹周围伪影的眼睛之间这些参数的分布情况。
在126名健康受试者中，12人（9.5%）的RGC+概率图上有异常的中心凹周围区域（伪影）。基于三个解剖参数的正态分布，12只眼中只有3只（25%）落在三个中央凹形态学参数中一个或多个参数的95%置信区间之外。多变量逻辑回归显示，参数斜率与这些伪影的存在显著相关（优势比 = 0.26；P = 0.019）。然而，这些参数与年龄的组合仅解释了这些伪影总方差的11%。
基于宽度、深度和斜率测量的中央凹形态在解释黄斑扫描中出现的伪影方面作用较小。RGC+厚度分布的变化在我们的测量中未得到体现，作为伪影的潜在来源值得进一步研究。
RGC+概率图上出现的一小部分中心凹周围伪影可由中央凹解剖结构的变化来解释。
