降钙素原与 C-反应蛋白对新生儿败血症诊断价值的比较研究。
A Comparative Evaluation of Presepsin with Procalcitonin and CRP in Diagnosing Neonatal Sepsis.
机构信息
Department of Pediatrics, Sarojini Naidu Medical College, Agra, India.
Department of Pediatrics, FH Medical College, Tundla, India.
出版信息
Indian J Pediatr. 2019 Feb;86(2):177-179. doi: 10.1007/s12098-018-2659-3. Epub 2018 Mar 26.
The objectives of this study were to study the clinical and biochemical profile of neonates with sepsis and to evaluate the diagnostic role of presepsin and its comparison with C-reactive protein (CRP) and Procalcitonin (PCT). This study was conducted from March 2015 through October 2016 in Neonatal intensive care unit (NICU) at S N Medical College, Agra. Neonates with ≥1 clinical features of sepsis and/or two risk factors were included. A total of 41 cases and 41 controls were taken. Blood sample was taken for all investigations. ROC curve analysis was performed. Out of 41 cases, 19 were blood culture positive, majority were males (68.3%), low birth weight (LBW: 70.7%) and preterms (53.6%). At chosen cut-off values, sensitivity of CRP, PCT and presepsin was 80.5%, 80.5%, 97.6% and specificity was 97.5%, 80.5%, 95.1% respectively. PCT and CRP were comparable as diagnostic markers of neonatal sepsis. Presepsin, in comparison with CRP and PCT has better sensitivity and negative predictive value (NPV).
本研究旨在研究脓毒症新生儿的临床和生化特征，并评估前肽素的诊断价值及其与 C 反应蛋白（CRP）和降钙素原（PCT）的比较。本研究于 2015 年 3 月至 2016 年 10 月在agra 的 S N 医学院新生儿重症监护病房（NICU）进行。纳入具有≥1 项脓毒症临床特征和/或 2 项危险因素的新生儿。共纳入 41 例病例和 41 例对照。对所有研究对象均采集血样进行检测。并进行 ROC 曲线分析。在 41 例病例中，19 例血培养阳性，大多数为男性（68.3%），低出生体重儿（LBW：70.7%）和早产儿（53.6%）。在选定的临界值下，CRP、PCT 和前肽素的敏感性分别为 80.5%、80.5%、97.6%，特异性分别为 97.5%、80.5%、95.1%。PCT 和 CRP 均可作为新生儿脓毒症的诊断标志物。与 CRP 和 PCT 相比，前肽素具有更高的敏感性和阴性预测值（NPV）。
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