Togo Yoshikazu, Ichioka Daishi, Miyazaki Jun, Maeda Yoshiko, Kameyama Koji, Yasuda Mitsuru, Hiyama Yoshiki, Takahashi Satoshi, Nagae Hiroshi, Hirota Seiichi, Yamamoto Shingo
Department of Urology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Int J Urol. 2018 May;25(5):479-485. doi: 10.1111/iju.13549. Epub 2018 Mar 25.
To assess the effect of cernitin pollen extract on serum prostate-specific antigen level prostate biopsy candidates, and to develop an ideal protocol to avoid an unnecessary biopsy procedure.
A total of 61 patients were administrated cernitin pollen extract tablets (two tablets t.i.d.) for 30 days, and then underwent a prostate biopsy with ≥12 systematic and targeted biopsy cores obtained. Serum prostate-specific antigen levels were examined before and after administration of the pollen extract, and the change in serum prostate-specific antigen and the rate of change were analyzed in relation to negative and positive biopsy results for cancer.
The mean change in serum prostate-specific antigen and rate of change after administration of cernitin pollen extract in all patients were -0.6 ± 1.4 ng/mL and -7.6 ± 16.1%, respectively, which were significantly different from the baseline values (P = 0.0003 and P = 0.0005, respectively). When prostate-specific antigen change values and rates were compared between patients negative and positive for cancer, a significant difference between those groups was observed (P = 0.04 and P = 0.03, respectively).
The present study is the first to show that an ideal protocol using cernitin pollen extract has the potential to avoid an unnecessary prostate biopsy procedure in patients with elevated prostate-specific antigen, possibly caused by inflammation. Additional studies with greater numbers of participants are required to confirm our findings and develop an ideal protocol.
评估舍尼通花粉提取物对前列腺活检候选者血清前列腺特异性抗原水平的影响，并制定理想方案以避免不必要的活检程序。
总共61例患者服用舍尼通花粉提取物片剂（每日三次，每次两片），持续30天，然后进行前列腺活检，获取≥12个系统和靶向活检组织。在服用花粉提取物前后检测血清前列腺特异性抗原水平，并分析血清前列腺特异性抗原的变化及其变化率与癌症活检阴性和阳性结果的关系。
所有患者服用舍尼通花粉提取物后血清前列腺特异性抗原的平均变化及其变化率分别为-0.6±1.4 ng/mL和-7.6±16.1%，与基线值有显著差异（分别为P = 0.0003和P = 0.0005）。比较癌症阴性和阳性患者的前列腺特异性抗原变化值和变化率时，两组之间存在显著差异（分别为P = 0.04和P = 0.03）。
本研究首次表明，使用舍尼通花粉提取物的理想方案有可能避免对前列腺特异性抗原升高（可能由炎症引起）的患者进行不必要的前列腺活检程序。需要更多参与者的进一步研究来证实我们的发现并制定理想方案。
