Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Integrated Research Center for Fetal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Am J Reprod Immunol. 2018 May;79(5):e12850. doi: 10.1111/aji.12850. Epub 2018 Mar 25.
Pregnancy is a state of immunotolerance and loss of this immunotolerance may lead to fetal rejection, pregnancy complications, and neonatal complications. Immunobiology of pregnancy is complex and involves unique immune cell populations specific to pregnancy, changes in mucosal immune cells and peripheral immune system, and reciprocal adaptations between the mother and the fetus. The mechanisms required for sustaining a healthy feto-placental barrier and a healthy pregnancy such as activation of regulatory immune responses with a predominance of regulatory T cells lead to immune evasion and propagation of cancer. It is intriguing to note that the immune pathways which are effective in limiting or eliminating cancer form the very basis for loss of feto-maternal tolerance. In this article, we aim to compare and contrast immunobiology of healthy and pathological pregnancies mirroring with cancer immunobiology with a focus on immune checkpoint receptors.
妊娠是一种免疫耐受状态，这种免疫耐受的丧失可能导致胎儿排斥、妊娠并发症和新生儿并发症。妊娠的免疫生物学非常复杂，涉及到妊娠特异性的独特免疫细胞群体、黏膜免疫细胞和外周免疫系统的变化，以及母亲和胎儿之间的相互适应。维持健康的胎-胎盘屏障和健康妊娠所需的机制，如调节性免疫反应的激活，以调节性 T 细胞为主导，导致免疫逃逸和癌症的传播。有趣的是，在限制或消除癌症方面有效的免疫途径，正是导致胎-母免疫耐受丧失的基础。在本文中，我们旨在比较和对比健康和病理性妊娠的免疫生物学，与癌症免疫生物学相呼应，重点关注免疫检查点受体。
