Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, Hungary.
Janos Szentagothai Research Centre, Pécs, Hungary.
Front Immunol. 2019 Apr 18;10:846. doi: 10.3389/fimmu.2019.00846. eCollection 2019.
Immune checkpoint molecules, like CTLA-4, TIM-3, PD-1, are negative regulators of immune responses to avoid immune injury. Checkpoint regulators are thought to actively participate in the immune defense of infections, prevention of autoimmunity, transplantation, and tumor immune evasion. Maternal-fetal immunotolerance represents a real immunological challenge for the immune system of the mother: beside acceptance of the semiallogeneic fetus, the maternal immune system has to be prepared for immune defense mostly against infections. In this particular situation, the role of immune checkpoint molecules could be of special interest. In this review, we describe current knowledge on the role of immune checkpoint molecules in reproductive immunology.
免疫检查点分子，如 CTLA-4、TIM-3、PD-1，是免疫反应的负调节剂，以避免免疫损伤。检查点调节剂被认为积极参与感染的免疫防御、预防自身免疫、移植和肿瘤免疫逃逸。母婴免疫耐受代表了母体免疫系统面临的真正免疫挑战：除了接受半同种异体胎儿外，母体免疫系统还必须为主要针对感染的免疫防御做好准备。在这种特殊情况下，免疫检查点分子的作用可能具有特殊意义。在这篇综述中，我们描述了免疫检查点分子在生殖免疫学中的作用的现有知识。
