School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110, Taiwan.
Division of Oral and Maxillofacial Surgery, Department of Dentistry, Taipei Medical University Hospital, Taipei, 110, Taiwan.
J Biomed Mater Res B Appl Biomater. 2019 Feb;107(2):278-285. doi: 10.1002/jbm.b.34118. Epub 2018 Mar 26.
In this study, the wound healing properties of the gelatin-based hydrogel (GBH) wound dressing combined with adipose-derived stem cells (ADSCs) were investigated using the mouse and porcine models. The analytical results showed that the ADSCs harvested from the porcine significantly increased cell growth and promoted cell differentiation (adipogenesis and osteogenesis) in comparison to the ADSCs harvested from the mouse in vitro. Moreover, the in vivo results also indicated that the GBH wound dressing combined with ADSCs and its culture medium could potentially accelerate wound healing in the mouse and porcine models. The ADSCs presented a possibility of recovery from wounds and injuries through skin regeneration. Therefore, both in vitro and in vivo results demonstrated that the ADSCs can potentially be an effective clinical treatment through the GBH wound dressing, which is a promising evidence-based complementary and alternative medicine for skin regeneration. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 278-285, 2019.
在这项研究中，使用小鼠和猪模型研究了基于明胶的水凝胶 (GBH) 伤口敷料与脂肪来源干细胞 (ADSCs) 联合的伤口愈合特性。分析结果表明，与从小鼠中分离的 ADSC 相比，从猪中分离的 ADSC 显著增加了细胞生长，并促进了细胞分化（脂肪生成和成骨）。此外，体内结果还表明，GBH 伤口敷料与 ADSC 及其培养基的组合有可能加速小鼠和猪模型中的伤口愈合。ADSC 通过皮肤再生有可能从伤口和损伤中恢复。因此，体外和体内结果均表明，ADSC 可通过 GBH 伤口敷料成为一种有效的临床治疗方法，这为皮肤再生提供了一种有前途的循证补充和替代医学方法。 © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 278-285, 2019.
