NFIA 和 NFIB 在食管鳞癌和食管胃结合部腺癌中的预后意义。
Prognostic significance of NFIA and NFIB in esophageal squamous carcinoma and esophagogastric junction adenocarcinoma.
机构信息
Department of General Thoracic Surgery, The General Hospital of PLA, Beijing, China.
Department of Digestive Disease, the Second affiliated hospital of Chongqing Medical University, Chongqing, China.
出版信息
Cancer Med. 2018 May;7(5):1756-1765. doi: 10.1002/cam4.1434. Epub 2018 Mar 25.
The nuclear factor I (NFI) family members, especially NFIA and NFIB, play essential roles in cancers. The roles of NFIA and NFIB in esophageal squamous cell carcinoma (ESCC) and esophagogastric junction adenocarcinoma (EJA) remain poorly known. This study aimed to determine the expression of NFIA and NFIB in ESCC and EJA and elucidate their prognostic significance. The expression of NFIA and NFIB was examined in 163 ESCC samples and 26 EJA samples by immunohistochemistry. The results showed that high NFIA expression correlated significantly with poor differentiation, lymph node metastasis, and advanced TNM stage in patients with ESCC. High NFIB expression only correlated with poor differentiation in patients with ESCC. Survival analysis showed that NFIA but not NFIB associated with short overall survival (OS) and disease-free survival (DFS) of patients with ESCC. On the other hand, high NFIB expression correlated with lymph node metastasis, advanced TNM stage, and short OS and DFS in patients with EJA. Finally, multivariate analysis demonstrated that high NFIA expression was an independent prognostic factor for ESCC. Taken together, these results demonstrated that NFIA and NFIB could serve as prognostic indicators for ESCC and EJA, respectively.
核因子 I（NFI）家族成员，尤其是 NFIA 和 NFIB，在癌症中发挥着重要作用。NFIA 和 NFIB 在食管鳞状细胞癌（ESCC）和食管胃交界腺癌（EJA）中的作用仍知之甚少。本研究旨在确定 NFIA 和 NFIB 在 ESCC 和 EJA 中的表达，并阐明其预后意义。通过免疫组织化学法检测了 163 例 ESCC 样本和 26 例 EJA 样本中 NFIA 和 NFIB 的表达。结果表明，在 ESCC 患者中，高 NFIA 表达与分化不良、淋巴结转移和晚期 TNM 分期显著相关。NFIB 高表达仅与 ESCC 患者的分化不良相关。生存分析表明，NFIA 与 ESCC 患者的总生存（OS）和无病生存（DFS）较短有关，但 NFIB 则无此相关性。另一方面，在 EJA 患者中，高 NFIB 表达与淋巴结转移、晚期 TNM 分期以及 OS 和 DFS 较短相关。最后，多因素分析表明，高 NFIA 表达是 ESCC 的独立预后因素。综上所述，这些结果表明 NFIA 和 NFIB 分别可作为 ESCC 和 EJA 的预后指标。
Zotero 插件