TGFBR3 是食管鳞癌的独立不良预后标志物，与 Ki-67 呈正相关。
TGFBR3 is an independent unfavourable prognostic marker in oesophageal squamous cell cancer and is positively correlated with Ki-67.
机构信息
Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
出版信息
Int J Exp Pathol. 2020 Dec;101(6):223-229. doi: 10.1111/iep.12380. Epub 2020 Nov 4.
The transforming growth factor beta (TGF-β) superfamily plays an important role in cancer development. One aspect of this is that the transforming growth factor beta receptor III (TGFBR3) is frequently overexpressed in some tumours. However, the role of TGFBR3 in oesophageal squamous cell carcinoma (ESCC) has not been explored as yet. In this study, we aimed to determine the role of TGFBR3 in the development and prognosis of ESCC and the correlation between TGFBR3 expression and Ki-67 and p53. Immunohistochemistry was performed to investigate the expression of TGFBR3 in the tumour tissue microarray consisting of ESCC tissues and matched adjacent normal tissues (n = 80). Only ESCC tissues (n = 20) were also used in our analysis. The association between TGFBR3 expression and clinicopathological characteristics, such as Ki-67 and p53, was analysed by Spearman's rank correlation coefficient analysis. The association between TGFBR3 expression and prognosis of ESCC was analysed using Kaplan-Meier analysis and log-rank tests. The expression levels of TGFBR3 in oesophageal cancer tissues were markedly higher than in matched adjacent normal tissues. Furthermore, TGFBR3 overexpression was significantly associated with tumour-node-metastasis (TNM) stage, lymph node metastasis (N stage) and Ki-67 expression. However, TGFBR3 overexpression was not significantly related to age, sex or p53. In univariate analysis, overall survival of ESCC patients was significantly associated with high TGFBR3 expression, sex, T stage, N stage and TNM stage. Moreover, ESCC patients with high TGFBR3 expression had poorer overall survival than those with low TGFB R3 expression. Our findings showed that TGFBR3 was upregulated in the development of human ESCC and high TGFBR3 expression was associated with high expression of Ki-67 and poor prognosis of ESCC. Therefore, TGFBR3 may be a valuable prognostic marker and a novel therapeutic target for ESCC.
转化生长因子-β（TGF-β）超家族在癌症的发展中起着重要作用。其中一个方面是，转化生长因子-β受体 III（TGFBR3）在一些肿瘤中经常过表达。然而，TGFBR3 在食管鳞状细胞癌（ESCC）中的作用尚未被探索。在这项研究中，我们旨在确定 TGFBR3 在 ESCC 的发生和预后中的作用，以及 TGFBR3 表达与 Ki-67 和 p53 的相关性。免疫组织化学分析用于研究包含 ESCC 组织和匹配的相邻正常组织的肿瘤组织微阵列中 TGFBR3 的表达（n=80）。仅对 20 例 ESCC 组织进行了我们的分析。采用 Spearman 秩相关系数分析分析 TGFBR3 表达与 Ki-67 和 p53 等临床病理特征之间的关系。采用 Kaplan-Meier 分析和对数秩检验分析 TGFBR3 表达与 ESCC 预后的关系。食管癌组织中 TGFBR3 的表达水平明显高于匹配的相邻正常组织。此外，TGFBR3 过表达与肿瘤-淋巴结-转移（TNM）分期、淋巴结转移（N 分期）和 Ki-67 表达显著相关。然而，TGFBR3 过表达与年龄、性别或 p53 无显著相关性。单因素分析显示，ESCC 患者的总生存率与 TGFBR3 高表达、性别、T 分期、N 分期和 TNM 分期显著相关。此外，TGFBR3 高表达的 ESCC 患者总生存率明显低于 TGFB R3 低表达的患者。我们的研究结果表明，TGFBR3 在人类 ESCC 的发生发展中被上调，高 TGFBR3 表达与 Ki-67 高表达和 ESCC 预后不良相关。因此，TGFBR3 可能是 ESCC 的一个有价值的预后标志物和新的治疗靶点。
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