Kay E A, Jayson M I
Scand J Rheumatol. 1987;16(4):241-5. doi: 10.3109/03009748709102924.
Two hundred and seventy-seven patients who had received gold sodium thiomalate (GST), were included in a retrospective study to identify those factors that might have influenced the development of side effects. Fifty-one per cent of patients were excluded due to side effects, especially skin rash, which affected 59% of those excluded. The duration of disease when GST therapy was commenced, female sex, and a history of smoking were identified as factors influencing the development of certain side effects. There was a high incidence of skin rash in smokers. Of 99 smokers, 40% developed dermatitis, whereas in 109 non-smokers, only 17% developed a rash (p less than 0.001). Other factors such as age, weight, and concurrent drug therapy, biochemical, haematological and immunological data, do not predict development of toxicity to GST.
277名接受硫代苹果酸钠金（GST）治疗的患者被纳入一项回顾性研究，以确定可能影响副作用发生的因素。51%的患者因副作用被排除，尤其是皮疹，受皮疹影响的患者占排除患者的59%。开始GST治疗时的病程、女性性别和吸烟史被确定为影响某些副作用发生的因素。吸烟者皮疹发生率很高。在99名吸烟者中，40%发生了皮炎，而在109名不吸烟者中，只有17%出现了皮疹（p小于0.001）。其他因素，如年龄、体重、同时进行的药物治疗、生化、血液学和免疫学数据，不能预测对GST的毒性发生。
