Toxalim (Research Centre in Food Toxicology), INRA, ENVT, INP-Purpan, UPS, Toulouse, France.
Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Neuroscience Paris Seine, Institut de Biologie Paris Seine, 75005 Paris, France.
Mol Cell Endocrinol. 2018 Nov 5;475:10-28. doi: 10.1016/j.mce.2018.02.007. Epub 2018 Mar 22.
Proper cyclicity is essential to reach successful optimal fertility. In rats and mice, BPA exposure is repeatedly and reliably reported to show an adverse effect on the estrous cycle after exposures at different life stages. In humans, a possible association between modifications of menstrual cycle characteristics (e.g. length of the cycle, duration of menstrual bleeding) and sub-fecundity or spontaneous abortion has been observed. Alterations of ovarian cyclicity can therefore be definitely considered as an adverse health outcome. As a prerequisite for the EU REACH regulation to identify a substance as an endocrine disruptor and a SVHC, the proof has to be established that the substance can have deleterious health effects resulting from an endocrine mode of action. This review provides an overview of the currently available data allowing to conclude that the adverse effects of BPA exposure on ovarian cyclicity is mediated by an endocrine mode of action.
适当的周期性对于达到最佳生育能力至关重要。在大鼠和小鼠中，反复且可靠地报道了 BPA 暴露会在不同生命阶段暴露后对发情周期产生不利影响。在人类中，已经观察到月经周期特征（例如周期长度、月经出血持续时间）的改变与生育力低下或自然流产之间可能存在关联。因此，可以肯定地认为卵巢周期性改变是一种不良健康后果。作为欧盟 REACH 法规将一种物质确认为内分泌干扰物和 SVHC 的前提条件，必须证明该物质可以通过内分泌作用模式产生有害的健康影响。这篇综述提供了目前可用数据的概述，使我们可以得出结论，BPA 暴露对卵巢周期性的不利影响是通过内分泌作用模式介导的。
