ANSES, Risk Assessment Department, Maisons-Alfort, France.
ANSES, Risk Assessment Department, Maisons-Alfort, France.
Mol Cell Endocrinol. 2018 Nov 5;475:92-106. doi: 10.1016/j.mce.2018.02.002. Epub 2018 Feb 8.
The extensive database on BPA provides strong evidence of its adverse effects on reproductive, neurobehavioural, metabolic functions and mammary gland. Disruption of estrogenic pathway is central in the mediation of these effects although other modes of action may be involved. BPA has a weak affinity for ERα/β but interaction with extranuclearly located pathways activated by estrogens such as ERRγ and GPER reveals how BPA can act at low doses. The effects are observed later in life after developmental exposure and are associated with pathologies of major societal concern in terms of severity, incidence, impact on quality of life, burden on public health system. The complexity of the dose response raise uncertainties on the possibility to establish safe levels and the scope of ED-mediated effects of BPA may be wider. These concerns fulfill the requirements for ED identification under REACH regulation.
BPA 的广泛数据库提供了强有力的证据，证明其对生殖、神经行为、代谢功能和乳腺有不良影响。尽管可能涉及其他作用模式，但雌激素途径的破坏是介导这些影响的核心。BPA 对 ERα/β 的亲和力较弱，但与雌激素激活的核外途径（如 ERRγ 和 GPER）相互作用，揭示了 BPA 如何在低剂量下发挥作用。这些影响在发育暴露后的生命后期出现，与社会严重关注的主要病理学有关，包括严重程度、发病率、对生活质量的影响、对公共卫生系统的负担。剂量反应的复杂性增加了建立安全水平的不确定性，BPA 的 ED 介导作用的范围可能更广泛。这些担忧符合 REACH 法规下 ED 识别的要求。
