Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Acta Oncol. 2019 Nov;58(11):1570-1576. doi: 10.1080/0284186X.2019.1657585. Epub 2019 Sep 11.
To evaluate changes in incidence and survival of patients diagnosed with hypopharyngeal cancer (HPC) in Denmark in the period 1980-2014. All patients registered with HPC in the Danish Cancer Registry (DCR) in the period 1980-2014 were included. Age-adjusted incidence rates (AAIRs), average annual percentage change in incidence, and overall survival were calculated. Two thousand and nine patients were included (79.7% men). The overall AAIR increased significantly from 0.3 per 100,000 to 1.1 per 100,000 during the study period, corresponding to an increase of 4.1% per year. The most frequent histology was squamous cell carcinoma (SCC) comprising 90.3%. The overall five-year survival increased with 13.5 percentage points from 13.4% in the period 1980-1985 to 26.9% in the period 2010-2014. Women demonstrated better survival compared to men with a hazard ratio of 0.83, and patients with SCC had better survival compared to the remaining histology groups. This nation-wide study, covering nearly four decades, showed a significant increase in incidence and survival of HPC in Denmark.
评估丹麦 1980 年至 2014 年期间诊断为下咽癌（HPC）的患者发病率和生存率的变化。本研究纳入了在 1980 年至 2014 年期间在丹麦癌症登记处（DCR）登记的所有 HPC 患者。计算了年龄调整发病率（AAIR）、发病率年均变化百分比和总生存率。共纳入了 2090 例患者（79.7%为男性）。在研究期间，总体 AAIR 从 0.3/100,000 显著增加到 1.1/100,000，每年增加 4.1%。最常见的组织学类型是鳞状细胞癌（SCC），占 90.3%。整体五年生存率从 1980-1985 年期间的 13.4%增加到 2010-2014 年期间的 26.9%，提高了 13.5 个百分点。与男性相比，女性的生存率更高，风险比为 0.83，与其他组织学类型相比，SCC 患者的生存率更高。这项涵盖近四十年的全国性研究表明，丹麦 HPC 的发病率和生存率显著增加。
