Noguchi Memorial Institute for Medical Research, University of Ghana, Legon.
Center for Medical Parasitology at Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
J Infect Dis. 2018 Jun 20;218(2):277-281. doi: 10.1093/infdis/jiy168.
Plasmodium falciparum parasites causing placental malaria express the VAR2CSA type of the clonally variant antigen family erythrocyte membrane protein 1 (PfEMP1). This enables evasion of preexisting immunity and results in placental accumulation of infected erythrocytes. We present data on seasonal variation in levels of VAR2CSA-specific immunoglobulin G (IgG) and IgG specific for a placental malaria-unrelated PfEMP1 protein among Ghanaian women at their first antenatal visit. Our results indicate that placental malaria does not require recent exposure to infected mosquitoes, in contrast to malaria in general. This has implications for the impact of insecticide-treated bed nets on placental malaria incidence and for antenatal care in woman with preexisting immunity.
疟原虫恶性疟原虫寄生虫引起胎盘疟疾表达的 VAR2CSA 型的无性系变异抗原家族红细胞膜蛋白 1 (PfEMP1)。这使得逃避预先存在的免疫，并导致胎盘积累感染的红细胞。我们提出的数据 VAR2CSA 特异性免疫球蛋白 G (IgG) 和 IgG 特定的胎盘疟疾无关 PfEMP1 蛋白在加纳妇女在他们的第一次产前检查。我们的结果表明，胎盘疟疾并不需要最近接触受感染的蚊子，与一般疟疾相反。这对杀虫剂处理的蚊帐对胎盘疟疾发病率的影响以及对具有预先存在免疫力的妇女的产前护理有影响。
