Korotaeva Alexandra A, Samoilova Elena V, Chepurnova Daria A, Zhitareva Irina V, Shuvalova Yulia A, Prokazova Nina V
a National Medical Research Center for Cardiology of the Ministry of Healthcare of the Russian Federation , Moscow , Russia.
b Medicobiologic Department , Pirogov Russian National Research Medical University , Moscow , Russia.
Biomarkers. 2018 Sep;23(6):527-532. doi: 10.1080/1354750X.2018.1458151. Epub 2018 Apr 26.
Recent studies indicate that the effects of interleukin 6 (IL-6) realized via soluble IL-6 receptor (sIL-6R) facilitate the development of various pathological processes. Soluble gp130 (sgp130) is a naturally occurring inhibitor of signal transduction via this pathway. In this study, we assessed the relationship between circulating levels of IL-6, sIL-6R and sgp130 and severity of coronary atherosclerosis in patients with stable coronary artery disease (CAD).
Plasma levels of IL-6, sIL-6R and sgp130 were measured in patients with atherosclerotic coronary lesions (n = 128, group 1) and with intact coronary arteries (n = 48, group 2). The severity of coronary atherosclerosis was evaluated by the number of affected arteries and by Gensini Score index.
Circulating IL-6 levels in group 1 were significantly higher than those in group 2. The levels of sIL-6R did not differ considerably in both the groups. The levels of sgp130 in group 1 were significantly lower than in group 2. A negative correlation has been revealed between sgp130 levels and the number of affected coronary arteries and Gensini Score index.
Serum concentration of sgp130 in patients with stable CAD is inversely related to severity of coronary damage. Low sgp130 level may serve as an additional indicator of coronary atherosclerosis severity.
近期研究表明，白细胞介素6（IL-6）通过可溶性IL-6受体（sIL-6R）发挥的作用促进了各种病理过程的发展。可溶性gp130（sgp130）是该信号转导途径的天然抑制剂。在本研究中，我们评估了稳定型冠状动脉疾病（CAD）患者循环中IL-6、sIL-6R和sgp130水平与冠状动脉粥样硬化严重程度之间的关系。
对有动脉粥样硬化性冠状动脉病变的患者（n = 128，第1组）和冠状动脉正常的患者（n = 48，第2组）测定血浆中IL-6、sIL-6R和sgp130的水平。通过受累动脉数量和Gensini评分指数评估冠状动脉粥样硬化的严重程度。
第1组的循环IL-6水平显著高于第2组。两组的sIL-6R水平差异不大。第1组的sgp130水平显著低于第2组。sgp130水平与受累冠状动脉数量和Gensini评分指数之间呈负相关。
稳定型CAD患者血清中sgp130浓度与冠状动脉损伤严重程度呈负相关。低sgp130水平可能是冠状动脉粥样硬化严重程度的一个额外指标。
