Mohamed Hesham, Aro Katri, Jouhi Lauri, Mäkitie Antti, Remes Satu, Haglund Caj, Atula Timo, Hagström Jaana
Department of Pathology, University of Helsinki, HusLab and Helsinki University Hospital, Haartmaninkatu 3, P.O. Box 21, 00014, Helsinki, Finland.
Department of Histology, Omar Al-Mukhtar University, AlBayda, Libya.
Eur Arch Otorhinolaryngol. 2018 May;275(5):1289-1300. doi: 10.1007/s00405-018-4949-9. Epub 2018 Mar 26.
Hormone receptors play an important role in many types of cancers. Alongside factors associated with human papillomavirus (HPV) infection, hormonal receptors may impact the tumorigenesis of oropharyngeal cancer.
This study consists of 199 consecutive oropharyngeal squamous cell carcinoma (OPSCC) patients diagnosed and treated with a curative intent. We examined androgen (AR), estrogen (ER; both alpha and beta), and progesterone receptor (PR) expressions using immunohistochemistry comparing tumor and patient characteristics.
AR was expressed in 16%, PR in 27% and ER-beta in 63% of the tumors. HPV- and p16-positive tumors expressed more AR and less PR than their negative counterparts. High PR expression was associated with poor disease-specific and locoregional recurrence-free survival.
AR, PR, and ER-beta are expressed in OPSCC, and AR and PR expressions are associated with HPV and p16 status. Furthermore, PR appears to have prognostic significance. This may allow us to investigate the role of anti-hormone receptors in the treatment of OPSCC.
激素受体在多种癌症中发挥重要作用。除了与人类乳头瘤病毒（HPV）感染相关的因素外，激素受体可能会影响口咽癌的肿瘤发生。
本研究纳入了199例连续的口咽鳞状细胞癌（OPSCC）患者，这些患者均被诊断为口咽鳞状细胞癌并接受了根治性治疗。我们使用免疫组织化学方法检测雄激素（AR）、雌激素（ER，包括α和β）和孕激素受体（PR）的表达，并比较肿瘤和患者的特征。
16%的肿瘤表达AR，27%的肿瘤表达PR，63%的肿瘤表达ER-β。HPV和p16阳性的肿瘤比阴性肿瘤表达更多的AR和更少的PR。高PR表达与较差的疾病特异性生存率和局部区域无复发生存率相关。
AR、PR和ER-β在OPSCC中表达，AR和PR的表达与HPV和p16状态相关。此外，PR似乎具有预后意义。这可能使我们能够研究抗激素受体在OPSCC治疗中的作用。
