Choi Gyuheon, Song Joon Seon, Choi Seung-Ho, Nam Soon Yuhl, Kim Sang Yoon, Roh Jong-Lyel, Lee Bu-Kyu, Cho Kyung-Ja
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
J Pathol Transl Med. 2019 Nov;53(6):369-377. doi: 10.4132/jptm.2019.09.16. Epub 2019 Oct 11.
The worldwide incidence of squamous cell carcinoma of the tongue (SCCOT) in young patients has been increasing. We investigated clinicopathologic features of this unique population and compared them with those of SCCOT in the elderly to delineate its pathogenesis.
We compared clinicopathological parameters between patients under and over 45 years old. Immunohistochemical assays of estrogen receptor, progesterone receptor, androgen receptor, p53, p16, mdm2, cyclin D1, and glutathione S-transferase P1 were also compared between them.
Among 189 cases, 51 patients (27.0%) were under 45 years of age. A higher proportion of women was seen in the young group, but was not statistically significant. Smoking and drinking behaviors between age groups were similar. Histopathological and immunohistochemical analysis showed no significant difference by age and sex other than higher histologic grades observed in young patients.
SCCOT in young adults has similar clinicopathological features to that in the elderly, suggesting that both progress via similar pathogenetic pathways.
年轻患者舌鳞状细胞癌（SCCOT）的全球发病率一直在上升。我们调查了这一独特人群的临床病理特征，并将其与老年SCCOT患者的特征进行比较，以阐明其发病机制。
我们比较了45岁以下和45岁以上患者的临床病理参数。还比较了他们之间雌激素受体、孕激素受体、雄激素受体、p53、p16、mdm2、细胞周期蛋白D1和谷胱甘肽S-转移酶P1的免疫组化检测结果。
在189例病例中，51例患者（27.0%）年龄在45岁以下。年轻组女性比例较高，但无统计学意义。各年龄组之间的吸烟和饮酒行为相似。组织病理学和免疫组化分析显示，除年轻患者组织学分级较高外，年龄和性别之间无显著差异。
年轻成年人的SCCOT与老年人具有相似的临床病理特征，提示两者通过相似的发病途径进展。
