利巴韦林对克里米亚-刚果出血热病毒（CCHFV）在感染克里米亚-刚果出血热的患者中的种群和载量具有明显作用。
Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient With CCHF Infection.
机构信息
US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland.
Arbovirus and Imported Viral Diseases Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III.
出版信息
J Infect Dis. 2018 May 25;217(12):1952-1956. doi: 10.1093/infdis/jiy163.
The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis of plasma samples obtained from a CCHFV-infected patient before, during, and after a 5-day regimen of ribavirin treatment. The CCHFV load dropped during ribavirin treatment, and subclonal diversity (transitions) and indels increased in viral genomes during treatment. Although the results are based on a single case, these data demonstrate the mutagenic effect of ribavirin on CCHFV in vivo.
利巴韦林治疗克里米亚-刚果出血热病毒（CCHFV）感染一直存在争议，这是基于临床病例研究中对其抗病毒疗效的不确定性。我们通过对一名感染 CCHFV 的患者在接受 5 天利巴韦林治疗前后的血浆样本进行深度测序分析，研究了利巴韦林治疗对近期病例中病毒群体的影响。在利巴韦林治疗期间，CCHFV 的载量下降，并且在治疗过程中病毒基因组中的亚克隆多样性（转换）和插入/缺失增加。尽管这些结果基于单个病例，但这些数据表明利巴韦林在体内对 CCHFV 具有诱变作用。
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