State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.
Viruses. 2021 Jun 22;13(7):1195. doi: 10.3390/v13071195.
Crimean-Congo hemorrhagic fever virus (CCHFV) is a widespread, tick-borne pathogen that causes Crimean-Congo hemorrhagic fever (CCHF) with high morbidity and mortality. CCHFV is transmitted to humans through tick bites or direct contact with patients or infected animals with viremia. Currently, climate change and globalization have increased the transmission risk of this biosafety level (BSL)-4 virus. The treatment options of CCHFV infection remain limited and there is no FDA-approved vaccine or specific antivirals, which urges the identification of potential therapeutic targets and the design of CCHF therapies with greater effort. In this article, we discuss the current progress and some future directions in the development of antiviral strategies against CCHFV.
克里米亚-刚果出血热病毒（CCHFV）是一种广泛存在的、经蜱传播的病原体，可引起克里米亚-刚果出血热（CCHF），具有较高的发病率和死亡率。CCHFV 通过蜱叮咬或直接接触有病毒血症的患者或感染动物传播给人类。目前，气候变化和全球化增加了这种生物安全级别 4（BSL-4）病毒的传播风险。CCHFV 感染的治疗选择仍然有限，且没有获得 FDA 批准的疫苗或特定的抗病毒药物，这促使人们更加努力地寻找潜在的治疗靶点和设计 CCHF 疗法。在本文中，我们讨论了针对 CCHFV 的抗病毒策略的最新进展和未来的一些发展方向。
