Laboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, University of Leuven, 3000 Leuven, Belgium.
School of Medicine, Jacqui Wood Cancer Centre, University of Dundee, Dundee DD1 9SY, UK.
Dev Cell. 2018 Mar 26;44(6):659-663. doi: 10.1016/j.devcel.2018.03.002.
Protein phosphorylation is a dynamic post-translational modification critical for biological responses. At the level of individual molecules, phosphorylation dynamics can have important functional implications, but this information is rarely quantified. We discuss how rapid phosphorylation-dephosphorylation cycles could underlie important signaling properties, including the ability to rapidly bind and release proteins.
蛋白质磷酸化是一种动态的翻译后修饰，对生物反应至关重要。在单个分子水平上，磷酸化动力学可能具有重要的功能意义，但这种信息很少被量化。我们讨论了快速的磷酸化-去磷酸化循环如何构成重要的信号特性的基础，包括快速结合和释放蛋白质的能力。
