Kwok Matthew Ming Kei, Lee Stewart, Hosking Patrick
Department of ENT, Eastern Health, Box Hill, Victoria, Australia.
Department of Pathology, Eastern Health, Box Hill, Victoria, Australia.
BMJ Case Rep. 2018 Mar 27;2018:bcr-2017-224110. doi: 10.1136/bcr-2017-224110.
Leiomyosarcomas (LMS) are rare sinonasal malignant tumours with 20 cases of nasal LMS previously reported in the literature. An 81-year-old man presented with an incidental left nasal lesion associated with left nasal obstruction and occasional left-sided blood-stained rhinorrhoea. Nasendoscopic examination showed green coloured polyps filling the left nasal cavity with biopsies showing LMS. CT imaging did not show any bony erosion. No metastases were found on positron emission tomography imaging. The patient underwent endoscopic resection and all surgical margins were clear of disease. The patient was declined postoperative radiotherapy, and serial follow-up has not shown any recurrence to date. Nasal LMS are rare sinonasal smooth muscle tumours and symptoms and radiological findings are often non-specific. Therefore, diagnosis is made on histopathological and immunohistochemical analysis. Due to their invasive nature, the treatment of choice is complete surgical resection, with adjuvant therapy reserved for patients with locally advanced or metastatic disease.
平滑肌肉瘤(LMS)是一种罕见的鼻窦恶性肿瘤,此前文献中报道过20例鼻腔LMS。一名81岁男性因偶然发现左侧鼻腔病变就诊,伴有左侧鼻塞和偶尔的左侧血性鼻漏。鼻内镜检查显示绿色息肉充满左侧鼻腔,活检显示为LMS。CT成像未显示任何骨质侵蚀。正电子发射断层显像未发现转移。患者接受了内镜下切除术,所有手术切缘均无肿瘤残留。患者拒绝术后放疗,至今系列随访未显示任何复发迹象。鼻腔LMS是罕见的鼻窦平滑肌肿瘤,症状和影像学表现通常不具有特异性。因此,诊断依靠组织病理学和免疫组织化学分析。由于其具有侵袭性,治疗的首选方法是完整的手术切除,辅助治疗适用于局部晚期或转移性疾病患者。