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一种具有独特重复序列且与IgG受体有同源性的IgE结合蛋白。

An IgE-binding protein with a distinctive repetitive sequence and homology with an IgG receptor.

作者信息

Albrandt K, Orida N K, Liu F T

机构信息

Division of Molecular Biology, Medical Biology Institute, La Jolla, CA 92037.

出版信息

Proc Natl Acad Sci U S A. 1987 Oct;84(19):6859-63. doi: 10.1073/pnas.84.19.6859.

DOI:10.1073/pnas.84.19.6859
PMID:2958848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC299184/
Abstract

Proteins that bind IgE play important roles in both the synthesis and function of IgE are therefore intimately involved in IgE-mediated human allergic disorders. This report describes the structure of an IgE-binding protein, as predicted from sequencing a cDNA cloned from rat basophilic leukemia cells. This protein contains two domains: the amino-terminal domain (140 amino acids) consists of a highly conserved repetitive amino acid sequence, Tyr-Pro-Gly-Pro/Gln-Ala/Thr-Pro/Ala-Pro-Gly-Ala, whereas the carboxyl-terminal domain (122 amino acids) shares significant sequence homology with a domain of lymphocyte/macrophage receptor for the Fc portion of IgG. Other proteins with this type of structure but with affinity for other immunoglobulin isotypes may exist and may represent a heretofore unidentified component of the immune system.

摘要

结合IgE的蛋白质在IgE的合成和功能中都起着重要作用，因此与IgE介导的人类过敏性疾病密切相关。本报告描述了一种IgE结合蛋白的结构，该结构是通过对从大鼠嗜碱性白血病细胞克隆的cDNA进行测序预测得到的。这种蛋白质包含两个结构域：氨基末端结构域（140个氨基酸）由高度保守的重复氨基酸序列Tyr-Pro-Gly-Pro/Gln-Ala/Thr-Pro/Ala-Pro-Gly-Ala组成，而羧基末端结构域（122个氨基酸）与IgG Fc部分的淋巴细胞/巨噬细胞受体的一个结构域具有显著的序列同源性。可能存在其他具有这种结构但对其他免疫球蛋白同种型具有亲和力的蛋白质，它们可能代表了迄今为止尚未被识别的免疫系统组成部分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4a7/299184/a39b30d0d0b6/pnas00334-0258-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4a7/299184/d306f0fecdae/pnas00334-0257-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4a7/299184/3d6e872d5e2f/pnas00334-0258-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4a7/299184/a39b30d0d0b6/pnas00334-0258-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4a7/299184/d306f0fecdae/pnas00334-0257-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4a7/299184/3d6e872d5e2f/pnas00334-0258-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4a7/299184/a39b30d0d0b6/pnas00334-0258-b.jpg

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