Altenkirch H U, Gerzer R, Kirsch K A, Weil J, Heyduck B, Schultes I, Röcker L
Landesleistungszentrum Berlin, Abt. Sportmedizin, Federal Republic of Germany.
Eur J Appl Physiol Occup Physiol. 1990;61(3-4):209-13. doi: 10.1007/BF00357601.
Sixteen well-trained young men performed a test marathon to study the behaviour of atrial natriuretic peptide (ANP) and its second messenger cyclic guanosine monophosphate (cGMP) in relation to changes in plasma volume (PV) and plasma proteins, arginine vasopressin (AVP), renin, aldosterone, potassium and sodium. Blood samples were drawn under standardized conditions before and immediately after the run, as well as 3 h and 31 h after the run. Directly after the run, a two-and-a-half fold increase of plasma ANP and a twofold increase of plasma cGMP level were found, whereas PV decreased significantly by 7.4%. At this time renin-, aldosterone- and AVP-secretion were much stimulated. Thirty-one hours after the run, PV was markedly greater (10%) than before the race, whereas plasma proteins had returned to pre-exercise values. The ANP and cGMP were not significantly altered compared to the pre-race values. We have concluded that ANP and the other volume-regulating hormones may play an important role during and immediately after prolonged physical exercise but not in the longer recovery period. It seems that an influx of plasma proteins into the vascular space is responsible for the increased PV at this time.
16名训练有素的年轻男性进行了一次测试马拉松，以研究心房利钠肽（ANP）及其第二信使环磷酸鸟苷（cGMP）与血浆容量（PV）、血浆蛋白、精氨酸加压素（AVP）、肾素、醛固酮、钾和钠变化的关系。在跑步前、跑步后即刻以及跑步后3小时和31小时，在标准化条件下采集血样。跑步后即刻，血浆ANP增加了2.5倍，血浆cGMP水平增加了2倍，而PV显著下降了7.4%。此时，肾素、醛固酮和AVP的分泌受到极大刺激。跑步后31小时，PV比比赛前明显增加（10%），而血浆蛋白已恢复到运动前水平。与赛前值相比，ANP和cGMP没有显著变化。我们得出结论，ANP和其他容量调节激素可能在长时间体育锻炼期间及之后即刻发挥重要作用，但在较长的恢复期则不然。此时，血浆蛋白流入血管腔似乎是PV增加的原因。
