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本文引用的文献

1
Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis.衰老与帕金森病：炎症衰老、神经炎症和生物重塑作为发病机制中的关键因素。
Free Radic Biol Med. 2018 Feb 1;115:80-91. doi: 10.1016/j.freeradbiomed.2017.10.379. Epub 2017 Nov 25.
2
Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels.腺苷受体：脂质可用性的调节剂，受脂质水平控制。
Mol Aspects Med. 2017 Jun;55:26-44. doi: 10.1016/j.mam.2017.01.007. Epub 2017 Jan 31.
3
Health benefits of methylxanthines in neurodegenerative diseases.甲基黄嘌呤在神经退行性疾病中的健康益处。
Mol Nutr Food Res. 2017 Jun;61(6). doi: 10.1002/mnfr.201600670. Epub 2017 Feb 22.
4
A2A adenosine receptor antagonists to weaken the hypoxia-HIF-1α driven immunosuppression and improve immunotherapies of cancer.A2A腺苷受体拮抗剂可减弱缺氧-HIF-1α驱动的免疫抑制作用，并改善癌症免疫治疗效果。
Curr Opin Pharmacol. 2016 Aug;29:90-6. doi: 10.1016/j.coph.2016.06.009. Epub 2016 Jul 17.
5
Neuroprotection by caffeine in the MPTP model of parkinson's disease and its dependence on adenosine A2A receptors.咖啡因在帕金森病MPTP模型中的神经保护作用及其对腺苷A2A受体的依赖性。
Neuroscience. 2016 May 13;322:129-37. doi: 10.1016/j.neuroscience.2016.02.035. Epub 2016 Feb 22.
6
High-Dose Adenosine for Treatment of Refractory Supraventricular Tachycardia in an Emergency Department of an Academic Medical Center: A Case Report and Literature Review.学术医学中心急诊科大剂量腺苷治疗难治性室上性心动过速：病例报告及文献综述
J Emerg Med. 2016 Mar;50(3):477-81. doi: 10.1016/j.jemermed.2015.11.012. Epub 2016 Jan 23.
7
Mechanism, diagnosis, and treatment of outflow tract tachycardia.流出道心动过速的机制、诊断和治疗。
Nat Rev Cardiol. 2015 Oct;12(10):597-608. doi: 10.1038/nrcardio.2015.121. Epub 2015 Aug 18.
8
Elucidating the role of the A2A adenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs.利用源自亨廷顿舞蹈病诱导多能干细胞的神经元阐明A2A腺苷受体在神经退行性变中的作用。
Hum Mol Genet. 2015 Nov 1;24(21):6066-79. doi: 10.1093/hmg/ddv318. Epub 2015 Aug 11.
9
Purinergic signaling in Parkinson's disease. Relevance for treatment.帕金森病中的嘌呤能信号传导。治疗相关性。
Neuropharmacology. 2016 May;104:161-8. doi: 10.1016/j.neuropharm.2015.07.024. Epub 2015 Jul 23.
10
Alternatively activated microglia and macrophages in the central nervous system.中枢神经系统中被替代激活的小胶质细胞和巨噬细胞。
Prog Neurobiol. 2015 Aug;131:65-86. doi: 10.1016/j.pneurobio.2015.05.003. Epub 2015 Jun 8.

Adenosine A Receptor Antagonists in Neurodegenerative Diseases: Huge Potential and Huge Challenges.

作者信息

Franco Rafael, Navarro Gemma

机构信息

Department of Biochemistry and Molecular Biomedicine, School of Biology, Universidad de Barcelona, Barcelona, Spain.

Centro de Investigación en Red, Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.

出版信息

Front Psychiatry. 2018 Mar 12;9:68. doi: 10.3389/fpsyt.2018.00068. eCollection 2018.

DOI:10.3389/fpsyt.2018.00068
PMID:29593579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5857539/
Abstract
摘要