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前列腺癌研究的未来:整合数据,回顾与展望。

The future of prostate cancer research: bringing data together, looking back and forward.

作者信息

Bangma Chris, Obbink Henk

机构信息

Department of Urology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

出版信息

Transl Androl Urol. 2018 Feb;7(1):188-194. doi: 10.21037/tau.2017.12.32.

DOI:10.21037/tau.2017.12.32
PMID:29594033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5861293/
Abstract

The use of digital data in large data sets will be of pivotal importance to unravel the biological basis of prostate cancer, and to improve on prevention and treatment. For the screening of asymptomatic tumors, their identification, and their treatment with better and targeted therapies, the integration of information from imaging, genomics, and biomarkers is needed. To bring these (un)structured data together, block chain technology is required, while knowledgeable analysts should be available. Therefore, it is of utmost importance to 'team up' and provide a common strategy for innovation. Its implementation needs the involvement of all stakeholders (patients, industries, professionals, scientists, governments). This article provides thoughts on how initial steps in urology have been taken, and how to proceed.

摘要

在大数据集中使用数字数据对于揭示前列腺癌的生物学基础以及改善预防和治疗至关重要。对于无症状肿瘤的筛查、识别以及采用更好的靶向疗法进行治疗,需要整合来自影像学、基因组学和生物标志物的信息。为了将这些(非)结构化数据整合在一起,需要区块链技术,同时要有知识渊博的分析师。因此,“携手合作”并提供共同的创新策略至关重要。其实施需要所有利益相关者(患者、行业、专业人士、科学家、政府)的参与。本文就泌尿外科已采取的初步措施以及如何继续推进提供了思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e3/5861293/de7f621e9a53/tau-07-01-188-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e3/5861293/0a33f0e2b901/tau-07-01-188-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e3/5861293/de7f621e9a53/tau-07-01-188-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e3/5861293/0a33f0e2b901/tau-07-01-188-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0e3/5861293/de7f621e9a53/tau-07-01-188-f2.jpg

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引用本文的文献

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本文引用的文献

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Identification of key pathways and genes with aberrant methylation in prostate cancer using bioinformatics analysis.利用生物信息学分析鉴定前列腺癌中甲基化异常的关键通路和基因。
Onco Targets Ther. 2017 Oct 10;10:4925-4933. doi: 10.2147/OTT.S144725. eCollection 2017.
2
Reconciling the Effects of Screening on Prostate Cancer Mortality in the ERSPC and PLCO Trials.调和欧洲随机前列腺癌筛查研究(ERSPC)和前列腺、肺癌、结直肠癌和卵巢癌筛查试验(PLCO)中筛查对前列腺癌死亡率的影响。
Ann Intern Med. 2017 Oct 3;167(7):449-455. doi: 10.7326/M16-2586. Epub 2017 Sep 5.
3
Prognostic Biomarkers Used for Localised Prostate Cancer Management: A Systematic Review.
用于局限性前列腺癌管理的预后生物标志物:系统评价。
Eur Urol Focus. 2018 Dec;4(6):790-803. doi: 10.1016/j.euf.2017.02.017. Epub 2017 Mar 7.
4
Active surveillance for prostate cancer: a narrative review of clinical guidelines.主动监测前列腺癌:临床指南的叙述性综述。
Nat Rev Urol. 2016 Mar;13(3):151-67. doi: 10.1038/nrurol.2015.313. Epub 2016 Jan 27.
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Absolute Effect of Prostate Cancer Screening: Balance of Benefits and Harms by Center within the European Randomized Study of Prostate Cancer Screening.前列腺癌筛查的绝对效果:欧洲前列腺癌筛查随机研究中各中心的利弊权衡
Clin Cancer Res. 2016 Jan 1;22(1):243-9. doi: 10.1158/1078-0432.CCR-15-0941. Epub 2015 Aug 19.
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Prevention and early detection of prostate cancer.前列腺癌的预防和早期发现。
Lancet Oncol. 2014 Oct;15(11):e484-92. doi: 10.1016/S1470-2045(14)70211-6.
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Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer.下一代测序揭示了具有前列腺癌功能意义的新型罕见融合事件。
Oncogene. 2015 Jan 29;34(5):568-77. doi: 10.1038/onc.2013.591. Epub 2014 Feb 3.