Hunan Provincial Key Laboratory of Dong Medicine, Hunan University of Medicine, Huaihua, 418000, People's Republic of China.
Hunan Engineering Laboratory for Preparation Technology of Polyvinyl Alcohol Fiber Material, College of Chemistry and Materials Engineering, Huaihua University, Huaihua, 418000, People's Republic of China.
Mikrochim Acta. 2017 Dec 20;185(1):70. doi: 10.1007/s00604-017-2613-5.
An electrochemical quercetin (QR) sensor is described that is based on the use of magnetic reduced graphene oxide (MrGO) incorporated into a molecularly imprinted polymer (MIP) on the surface of a screen-printed electrode (SPE). The MrGO consists of reduced graphene oxide (rGO), magnetite (FeO) and silver nanoparticles (Ag). The analyte (QR) is electrostatically adsorbed on the surface of the MrGO. Finally, the MIP was deposited via in-situ polymerization. The composite was characterized by X-ray diffraction, Fourier transform infrared spectroscopy and Vibrating sample magnetometry. The morphologies and electrochemical properties of different electrodes were characterized by Field emission scanning electron microscopy, Electrochemical impedance spectroscopy and differential pulse voltammetry. Under optimal conditions, the modified electrode has a linear response in the 20 nM to 250 μM QR concentration range. The limit of detection is 13 nM (at an S/N ratio of 3). The electrode is selective, stable, regenerable and reliable. It was applied to the determination of QR in spiked pharmaceutical samples and gave satisfactory results. Graphical abstract Schematic presentation of a method for sensing quercetin. It is based on the use of screen printed electrode modified with magnetized reduced graphene oxide and a molecularly imprinted polymer.
电化学槲皮素（QR）传感器是基于在丝网印刷电极（SPE）表面上使用掺入分子印迹聚合物（MIP）的磁性还原氧化石墨烯（MrGO）而构建的。MrGO 由还原氧化石墨烯（rGO）、磁铁矿（FeO）和银纳米粒子（Ag）组成。分析物（QR）通过静电吸附在 MrGO 的表面上。最后，通过原位聚合沉积 MIP。通过 X 射线衍射、傅里叶变换红外光谱和振动样品磁强计对复合材料进行了表征。通过场发射扫描电子显微镜、电化学阻抗谱和差分脉冲伏安法对不同电极的形貌和电化学性能进行了表征。在最佳条件下，修饰电极在 20 nM 至 250 μM QR 浓度范围内具有线性响应。检测限为 13 nM（信噪比为 3）。该电极具有选择性、稳定性、可再生性和可靠性。它被用于测定加标药物样品中的 QR，结果令人满意。
