基于 MnO 纳米片门控介孔硅纳米粒子的谷胱甘肽检测及便携式血糖仪测量的靶标诱导的葡萄糖释放
Detection of glutathione based on MnO nanosheet-gated mesoporous silica nanoparticles and target induced release of glucose measured with a portable glucose meter.
机构信息
College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu, Shandong, 273165, People's Republic of China.
Beijing Key Laboratory of Ionic Liquids Clean Process, Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.
出版信息
Mikrochim Acta. 2017 Dec 8;185(1):44. doi: 10.1007/s00604-017-2603-7.
The authors describe a novel method for the determination of glutathione (GSH). Detection is based on target induced release of glucose from MnO nanosheet-gated aminated mesoporous silica nanoparticles (MSNs). In detail, glucose is loaded into the pores of MSNs. Negatively charged MnO nanosheets are assembled on the MSNs through electrostatic interactions. The nanosheets are reduced by GSH, and this results in the release of glucose which is quantified by using a commercial electrochemical glucose meter. GSH can be quantified by this method in the 100 nM to 10 μM concentration range, with a 34 nM limit of detection. Graphical abstract Glucose is loaded into the pores of mesoporous silica nanoparticles (MSNs). MnO nanosheets are assembled on MSNs through electrostatic interactions. Glutathione (GSH) can reduce the nanosheets, and this results in the release of glucose which is quantified by using a commercial glucose meter.
作者描述了一种测定谷胱甘肽（GSH）的新方法。检测基于 MnO 纳米片门控氨基介孔硅纳米粒子（MSNs）从目标物诱导释放葡萄糖。具体来说，葡萄糖被装载到 MSNs 的孔中。通过静电相互作用将带负电荷的 MnO 纳米片组装到 MSNs 上。GSH 可以还原纳米片，这导致葡萄糖的释放，并用商业电化学葡萄糖计进行定量。通过这种方法可以在 100 nM 至 10 μM 的浓度范围内定量 GSH，检测限为 34 nM。
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