College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institute of Molecular and Nano Science, Shandong Normal University , Jinan 250014, P.R. China.
ACS Appl Mater Interfaces. 2017 Jan 25;9(3):2123-2129. doi: 10.1021/acsami.6b13876. Epub 2017 Jan 9.
A size-controllable and facile synthetic strategy has been developed to fabricate a series of hollow mesoporous silica nanoparticles (HMSNs) with tunable hollow cores or shell thicknesses by employing gold nanoparticles (Au NPs) and cetyltrimethylammonium bromide (CTAB) as dual templates. Various sizes of Au NPs and different amounts of tetraethyl orthosilicate contributed to structure-tailored mesoporous silica-coated Au NPs. After calcination, CTAB molecules were completely removed, and Au NPs could still support the silica shell due to the high melting point. HMSNs were ultimately obtained by etching Au NPs. Applications of HMSNs as nanocarriers for delivering drugs were investigated. Significantly, it was flexible and convenient to control drug-loading/releasing behavior of HMSNs just by tuning the hollow cores or shell thicknesses. Intracellular experiments have proven that HMSNs are suitable for delivering drugs. We anticipate that this study could provide an important avenue for the synthesis of HMSNs and further contribute to advancing practical applications of HMSNs in drug delivery systems.
已经开发出一种可控制尺寸且简便的合成策略，通过使用金纳米颗粒 (Au NPs) 和十六烷基三甲基溴化铵 (CTAB) 作为双重模板，可制备一系列具有可调空心核或壳厚度的中空介孔硅纳米颗粒 (HMSNs)。不同尺寸的 Au NPs 和不同量的正硅酸乙酯有助于定制结构的介孔硅包覆的 Au NPs。煅烧后，CTAB 分子被完全去除，由于高熔点，Au NPs 仍能支撑硅壳。通过蚀刻 Au NPs 最终获得 HMSNs。研究了 HMSNs 作为药物输送纳米载体的应用。重要的是，通过调整空心核或壳厚度，可以灵活方便地控制 HMSNs 的药物加载/释放行为。细胞内实验已经证明 HMSNs 适合输送药物。我们预计这项研究可为 HMSNs 的合成提供重要途径，并进一步推动 HMSNs 在药物输送系统中的实际应用。
