Puurunen J, Ruskoaho H
Department of Pharmacology, University of Oulu, Finland.
Eur J Pharmacol. 1987 Sep 23;141(3):493-5. doi: 10.1016/0014-2999(87)90572-3.
The intracerebroventricular (i.c.v.) administration of 10 micrograms of atrial natriuretic peptide (ANP) stimulated spontaneous gastric acid secretion in anaesthetized rats, whereas this dose of ANP was without any effect after i.v. injection. The secretagogue action of i.c.v. administered ANP was totally abolished by truncal vagotomy. The findings indicate that i.c.v. administration of ANP stimulates gastric acid secretion in anaesthetized rats by a central, vagal-dependent mechanism.
向麻醉大鼠脑室内注射10微克心钠素（ANP）可刺激胃酸自发分泌，而静脉注射此剂量的心钠素则无任何作用。经迷走神经干切断术后，脑室内注射心钠素的促分泌作用完全消失。这些发现表明，脑室内注射心钠素通过中枢迷走神经依赖机制刺激麻醉大鼠的胃酸分泌。
