Service de Dermatologie, Hôpital Victor Dupouy, 69 rue du Lieutenant-Colonel Prud'hon, 95100, Argenteuil, France.
Unité de Dermatologie Pédiatrique, Hôpital Pellegrin-Enfants, Bordeaux, France.
Am J Clin Dermatol. 2018 Aug;19(4):609-615. doi: 10.1007/s40257-018-0354-9.
Psoriasis affects 2-4% of the population, with the most common clinical type being plaque psoriasis. The linear form of psoriasis is very rare. The literature on linear psoriasis (LP) consists of only case reports, and data are few.
This study aimed to better understand LP in a large-scale study.
We retrospectively retrieved the medical records from 14 French medical centers of patients newly diagnosed clinically with LP, with or without the support of histology, between 1 February and 31 July 2015. For each case, we assessed the clinical features, treatments and treatment efficacy.
In total, 30 cases of LP (mean age 26.8 years, 13 males) were reported. Mean age at onset of LP was 20.0 years, with 18 developing LP in childhood. Ten patients had a family history of psoriasis, and two had psoriatic arthritis. A total of 19 cases were linear at onset, with concomitant classical psoriasis; these were termed "superimposed" LP. The remaining 11 cases were not associated with classical psoriasis and were termed "isolated" LP. In four of the superimposed cases, LP developed when the patient was receiving systemic treatment: methotrexate (n = 2), etanercept (n = 1) or infliximab (n = 1). Topical steroids were effective in 76% of cases in which they were used, and systemic treatment was effective in < 66%. Treatments were less effective in LP than in classical psoriasis.
We identified a wide range of LP, with two profiles: isolated LP and superimposed LP. Topical treatment usually evoked clinical response, with relative resistance to systemic therapy. Methotrexate and anti-tumor necrosis factor (TNF)-α therapies can possibly unmask LP.
银屑病影响人群的 2-4%，最常见的临床类型为斑块型银屑病。银屑病的线性形式非常罕见。关于线性银屑病（LP）的文献仅包含病例报告，数据很少。
本研究旨在通过大规模研究更好地了解 LP。
我们回顾性检索了 2015 年 2 月 1 日至 7 月 31 日期间，14 家法国医疗中心新诊断为临床 LP（有或无组织学支持）的患者的病历。对于每个病例，我们评估了临床特征、治疗和治疗效果。
共报告 30 例 LP（平均年龄 26.8 岁，男性 13 例）。LP 的发病平均年龄为 20.0 岁，18 例在儿童时期发病。10 例患者有银屑病家族史，2 例有银屑病关节炎。共有 19 例患者 LP 起病呈线性，同时伴有经典银屑病，这些被称为“重叠”LP。其余 11 例与经典银屑病无关，称为“孤立”LP。在重叠的 4 例中，当患者接受全身治疗时 LP 发病：甲氨蝶呤（n=2）、依那西普（n=1）或英夫利昔单抗（n=1）。局部皮质类固醇在使用的 76%病例中有效，全身治疗有效率<66%。治疗在 LP 中的疗效不及经典银屑病。
我们发现了广泛的 LP，有两种类型：孤立性 LP 和重叠性 LP。局部治疗通常引起临床反应，对全身治疗的耐药性相对较低。甲氨蝶呤和抗肿瘤坏死因子（TNF）-α 治疗可能会使 LP 显现。
