State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Jiangsu Key Laboratory of Drug Screening , China Pharmaceutical University , Nanjing 210009 , P. R. China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences , University of Macau , Macao , China.
Org Lett. 2018 Apr 20;20(8):2164-2167. doi: 10.1021/acs.orglett.8b00423. Epub 2018 Mar 29.
A class of O-alkyl derived diazeniumdiolates 3a-f and 4a-c were designed and synthesized as new bioorthogonal NO precursors, which can be effectively uncaged in the presence of a palladium catalyst via bioorthogonal bond cleavage reactions to generate NO in living cancer cells, eliciting potent antiproliferative activity.
一类 O-烷基取代的重氮烷二酸盐 3a-f 和 4a-c 被设计并合成作为新型生物正交的 NO 前体，在钯催化剂的存在下通过生物正交键断裂反应可以有效地释放出 NO ，从而在活的癌细胞中产生强烈的抗增殖活性。
